Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

Abstract A balanced (1; 11)(q42. 1; q14. 3) translocation segregates with schizophrenia and
related psychiatric disorders in a large Scottish family (maximum LOD= 6.0). We hypothesize …

Previous observations have demonstrated that embryonic exposure to the endocrine
disruptor vinclozolin during gonadal sex determination promotes transgenerational adult …

Many environmental toxicants have been shown to be associated with the transgenerational
inheritance of increased disease susceptibility. This review describes the generational …

The H19 gene is imprinted with preferential expression from the maternal allele. The
putative imprinting control region for this locus is hypermethylated on the repressed paternal …

Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at
most a few percent of manipulated embryos resulting in live births. Many of those that …

Culture of preimplantation mammalian embryos and cells can influence their subsequent
growth and differentiation. Previously, we reported that culture of mouse embryonic stem …

Genetic information is encoded not only by the linear sequence of DNA, but also by
epigenetic modifications of chromatin structure that include DNA methylation and covalent …

The heterotrimeric G protein Gs couples hormone receptors (as well as other receptors) to
the effector enzyme adenylyl cyclase and is therefore required for hormone-stimulated …