There is mounting evidence that environmental exposures can result in effects on health that
can be transmitted across generations, without the need for a direct exposure to the original …

BACKGROUND: Turner syndrome (TS) results from complete or partial monosomy X. The
cognitive phenotype of TS involves preservation of verbal skills with visuospatial functioning …

Mammalian genomic imprinting is regulated by imprinting control regions (ICRs) that are
usually associated with tandem arrays of transcription factor binding sites. In this study, the …

Epigenetic modifications direct the way DNA is packaged into the nucleus, making genes
more or less accessible to transcriptional machinery and influencing genomic stability …

Nucleic acids often acquire new functions by forming a variety of complexes with metal ions.
Osmium, in an oxidized state, also reacts with C5-methylated pyrimidines. However, control …

In mammalians, demethylation of specific promoter regions often correlates with gene
activation; inversely, dense methylation of CpG islands leads to gene silencing, probably …

Activating mutations of the GNAS gene, which causes fibrous dysplasia of bone (FD), lead to
remarkable changes in the properties of skeletal progenitors, and it is these changes that …

Endocrine-disrupting chemicals generally function as steroid receptor signaling antagonists
or agonists that influence development to promote adult-onset disease. Exposure to the …

Epigenetic regulation, such as DNA methylation plays an important role in the control of
imprinting. Lsh, a member of the SNF2 family of chromatin remodeling proteins, controls …

Precise and deliberate observations on tumors stand true for decades, and then meet
mechanistic explanations. The presence of genetic alterations in tumors is now widely …