Computational immunogenomic approaches to predict response to cancer immunotherapies
Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …
establishment of large-scale genomic collaborative efforts along with the development of …
Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human
tissue is important for understanding disease pathologies. However, several experimental …
tissue is important for understanding disease pathologies. However, several experimental …
Cell-free DNA methylome analysis for early preeclampsia prediction
M De Borre, H Che, Q Yu, L Lannoo, K De Ridder… - Nature Medicine, 2023 - nature.com
Preeclampsia (PE) is a leading cause for peripartal morbidity, especially if developing early
in gestation. To enable prophylaxis in the prevention of PE, pregnancies at risk of PE must …
in gestation. To enable prophylaxis in the prevention of PE, pregnancies at risk of PE must …
A mammalian methylation array for profiling methylation levels at conserved sequences
Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …
Moreover, even if species-specific arrays were available, probe differences between them …
Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas
Recurrence of meningiomas is unpredictable by current invasive methods based on
surgically removed specimens. Identification of patients likely to recur using noninvasive …
surgically removed specimens. Identification of patients likely to recur using noninvasive …
Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study
Epigenetic ageing, ie, age‐associated changes in DNA methylation patterns, is a sensitive
marker of biological ageing, a major determinant of morbidity and functional decline. We …
marker of biological ageing, a major determinant of morbidity and functional decline. We …
Eosinophils as potential biomarkers in respiratory viral infections
I Macchia, V La Sorsa, F Urbani, S Moretti… - Frontiers in …, 2023 - frontiersin.org
Eosinophils are bone marrow-derived granulocytes that, under homeostatic conditions,
account for as much as 1-3% of peripheral blood leukocytes. During inflammation …
account for as much as 1-3% of peripheral blood leukocytes. During inflammation …
HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type …
Background Cellular compositions of solid tumor microenvironments are heterogeneous,
varying across patients and tumor types. High-resolution profiling of the tumor …
varying across patients and tumor types. High-resolution profiling of the tumor …
Prospective epigenome and transcriptome analyses of cord and peripheral blood from preterm infants at risk of bronchopulmonary dysplasia
HY Cho, X Wang, MR Campbell, V Panduri… - Scientific Reports, 2023 - nature.com
Bronchopulmonary dysplasia (BPD) is a prevalent chronic lung disease of prematurity with
limited treatment options. To uncover biomarkers of BPD risk, this study investigated …
limited treatment options. To uncover biomarkers of BPD risk, this study investigated …
A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …
diseases and environmental risk factors and may be causally implicated in disease …