Pre-messenger RNA (pre-mRNA) splicing is a central step in gene expression. Lying
between transcription and protein synthesis, pre-mRNA splicing removes sequences …

Inteins are mobile genetic elements that apply standard enzymatic strategies to excise
themselves post-translationally from the precursor protein via protein splicing. Since their …

Prp8 is the largest and most highly conserved protein of the spliceosome, encoded by all
sequenced eukaryotic genomes but missing from prokaryotes and viruses. Despite all …

Self-splicing proteins, called inteins, are present in many human pathogens, including the
emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the …

A recent species status investigation of the pathogenic fungus Paracoccidioides brasiliensis
suggested the existence of three cryptic species. In the present study, the sequences of the …

The Prp8 intein is one of the most widespread eukaryotic inteins, present in important
pathogenic fungi, including Cryptococcus and Aspergillus species. Because the processed …

Background Inteins are mobile, self-splicing sequences that interrupt proteins and occur
across all three domains of life. Scrutiny of the intein landscape in prokaryotes led to the …

Comparative analyses of fungal genomes and molecular research on genes associated with
fungal viability and virulence has led to the identification of many putative targets for novel …

Only two nuclear encoded inteins have been described. The first, SceVMA, was found in a
vacuolar ATPase gene of Saccharomyces cerevisiae and related yeasts. The second …

Inteins are self-splicing intervening sequences in proteins, and inteins of pathogenic
organisms can be attractive drug targets. Here, we report an intein in important fungal …