Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Loss-of-function mutations in genes encoding TET DNA dioxygenase occur frequently in
hematopoietic malignancy, but rarely in solid tumors, which instead commonly have reduced …

Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …

Background Recently, the dysregulation of circular RNA (circRNA) have been shown to
have important regulatory roles in cancer development and progression, including …

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …

Nucleic acids carry a wide range of different chemical modifications. In contrast to previous
views that these modifications are static and only play fine-tuning functions, recent research …

DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer,
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …

S-nitrosylation, a prototypic redox-based posttranslational modification, is frequently
dysregulated in disease. S-nitrosoglutathione reductase (GSNOR) regulates protein S …

Background As an important means of communication, exosomes play an important role in
the development of hepatocellular carcinoma (HCC). Methods Bioinformatics analysis, dual …