Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Epigenetic age prediction
DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
DNA methylation clocks for dogs and humans
DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …
epigenetic clocks, which predict chronological age with remarkable accuracy and show …
DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders
Naked mole rats (NMRs) live an exceptionally long life, appear not to exhibit age-related
decline in physiological capacity and are resistant to age-related diseases. However, it has …
decline in physiological capacity and are resistant to age-related diseases. However, it has …
Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals
AM Dettmer, DE Chusyd - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Social nonhuman animals are powerful models for studying underlying factors related to
lifelong health outcomes following early life adversities (ELAs). ELAs can be linked to …
lifelong health outcomes following early life adversities (ELAs). ELAs can be linked to …
High social status males experience accelerated epigenetic aging in wild baboons
Aging, for virtually all life, is inescapable. However, within populations, biological aging rates
vary. Understanding sources of variation in this process is central to understanding the …
vary. Understanding sources of variation in this process is central to understanding the …
Biological clocks as age estimation markers in animals: a systematic review and meta‐analysis
LS Le Clercq, A Kotzé, JP Grobler… - Biological …, 2023 - Wiley Online Library
Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …
DNA methylation aging and transcriptomic studies in horses
Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …
DNA methylation‐based biomarkers for ageing long‐lived cetaceans
Epigenetic approaches for estimating the age of living organisms are revolutionizing studies
of long‐lived species. Molecular biomarkers that allow age estimates from small tissue …
of long‐lived species. Molecular biomarkers that allow age estimates from small tissue …