[HTML][HTML] Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
L Zhong, Y Li, L Xiong, W Wang, M Wu… - Signal transduction and …, 2021 - nature.com
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …
of DNA sequence. It requires interactions cohesively with various enzymes and other …
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
MB Pappalardi, K Keenan, M Cockerill, WA Kellner… - Nature cancer, 2021 - nature.com
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …
The roles of DNA, RNA and histone methylation in ageing and cancer
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …
and RNA. The methylation of chromatin components is highly conserved as it helps …
Magrolimab in combination with azacitidine in patients with higher-risk myelodysplastic syndromes: final results of a phase Ib study
DA Sallman, MM Al Malki, AS Asch… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Magrolimab is a monoclonal antibody that blocks cluster of differentiation 47, a
don't-eat-me signal overexpressed on cancer cells. Cluster of differentiation 47 blockade by …
don't-eat-me signal overexpressed on cancer cells. Cluster of differentiation 47 blockade by …
Myelodysplastic syndromes: 2023 update on diagnosis, risk‐stratification, and management
G Garcia‐Manero - American journal of hematology, 2023 - Wiley Online Library
Disease overview The myelodysplastic syndromes (MDS) are a very heterogeneous group
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …
A phase 3 randomized study of 5-azacitidine maintenance vs observation after transplant in high-risk AML and MDS patients
This study investigated the efficacy and safety of azacitidine maintenance in the
posttransplant setting based on the encouraging phase 1/2 reports for azacitidine …
posttransplant setting based on the encouraging phase 1/2 reports for azacitidine …
Endothelial cells orchestrate COVID-19 coagulopathy
JM O'Sullivan, D Mc Gonagle, SE Ward… - The Lancet …, 2020 - thelancet.com
Recent data have shown that coagulation activation is common in patients with severe
COVID-19. 1, 2 Moreover, autopsy studies have reported widespread microthrombi …
COVID-19. 1, 2 Moreover, autopsy studies have reported widespread microthrombi …
De novo acute myeloid leukemia: a population‐based study of outcome in the United States based on the Surveillance, Epidemiology, and End Results (SEER) …
K Sasaki, F Ravandi, TM Kadia, CD DiNardo… - Cancer, 2021 - Wiley Online Library
Background Several important treatment and supportive care strategies have been
implemented over the past 4 decades in the management of acute myeloid leukemia (AML) …
implemented over the past 4 decades in the management of acute myeloid leukemia (AML) …
[HTML][HTML] Gene body methylation can alter gene expression and is a therapeutic target in cancer
DNA methylation in promoters is well known to silence genes and is the presumed
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …