[HTML][HTML] Transgenerational epigenetic inheritance: myths and mechanisms
E Heard, RA Martienssen - Cell, 2014 - cell.com
Since the human genome was sequenced, the term" epigenetics" is increasingly being
associated with the hope that we are more than just the sum of our genes. Might what we …
associated with the hope that we are more than just the sum of our genes. Might what we …
Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health
O Babenko, I Kovalchuk, GAS Metz - Neuroscience & Biobehavioral …, 2015 - Elsevier
Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …
stressful experiences during pregnancy exert long-term consequences on the future mental …
Nurse cell–derived small RNAs define paternal epigenetic inheritance in Arabidopsis
J Long, J Walker, W She, B Aldridge, H Gao, S Deans… - Science, 2021 - science.org
INTRODUCTION Epigenetic modifications to chromatin, such as the methylation of DNA
cytosines, carry regulatory information across the generations in plants and animals …
cytosines, carry regulatory information across the generations in plants and animals …
[HTML][HTML] Epigenetic inheritance: concepts, mechanisms and perspectives
Parents' stressful experiences can influence the offspring's vulnerability to many
pathological conditions, including psychopathologies, and their effects may even endure for …
pathological conditions, including psychopathologies, and their effects may even endure for …
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
K Blaschke, KT Ebata, MM Karimi, JA Zepeda-Martínez… - Nature, 2013 - nature.com
DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …
[HTML][HTML] Understanding the relationship between DNA methylation and histone lysine methylation
DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …
become clear that the DNA and histone lysine methylation systems are highly interrelated …
[PDF][PDF] Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …
Epigenetic inheritance and the missing heritability
Genome-wide association studies of complex physiological traits and diseases consistently
found that associated genetic factors, such as allelic polymorphisms or DNA mutations, only …
found that associated genetic factors, such as allelic polymorphisms or DNA mutations, only …
An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells
DNA methylation is extensively remodeled during mammalian gametogenesis and
embryogenesis. Most transposons become hypomethylated, raising the question of their …
embryogenesis. Most transposons become hypomethylated, raising the question of their …
How do chemotherapeutic agents damage the ovary?
S Morgan, RA Anderson, C Gourley… - Human reproduction …, 2012 - academic.oup.com
BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …
increased risk of premature ovarian failure (POF) but the exact mechanism through which …