DectiSomes: C-type lectin receptor-targeted liposomes as pan-antifungal drugs

RB Meagher, ZA Lewis, S Ambati, X Lin - Advanced Drug Delivery Reviews, 2023 - Elsevier
Combatting the ever-increasing threat from invasive fungal pathogens faces numerous
fundamental challenges, including constant human exposure to large reservoirs of species …

Yeast biofilms on abiotic surfaces: adhesion factors and control methods

VPP Alonso, JG Lemos, MS do Nascimento - International journal of food …, 2023 - Elsevier
Biofilms are highly resistant to antimicrobials and are a common problem in many industries,
including pharmaceutical, food and beverage. Yeast biofilms can be formed by various yeast …

Synthetic glycans reveal determinants of antibody functional efficacy against a fungal pathogen

CJ Crawford, L Guazzelli, SA McConnell… - ACS Infectious …, 2023 - ACS Publications
Antibodies play a vital role in the immune response to infectious diseases and can be
administered passively to protect patients. In the case of Cryptococcus neoformans, a WHO …

Nanotechnology-based approaches for voriconazole delivery applied to invasive fungal infections

L de Almeida Campos, MT Fin, KS Santos… - Pharmaceutics, 2023 - mdpi.com
Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of
these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic …

Screening of exopolysaccharide-producing Enterobacter aerogenes NJ1023 and its cadaverine biosynthesis promotion

Y Xie, Z Ye, X Wan, H Deng, W Sun, X He… - Frontiers in …, 2023 - frontiersin.org
Enterobacter aerogenes, the gram-negative bacteria belonging to the family
Enterobacteriaceae, lacks the ability to synthesize chemicals. However, in this study, a strain …

Melaninization Reduces Cryptococcus neoformans Susceptibility to Mechanical Stress

ER Mattoon, RJB Cordero, A Casadevall - Msphere, 2023 - Am Soc Microbiol
Melanin is a complex pigment that is found in various fungal species and is associated with
a multitude of protective functions against environmental stresses. In Cryptococcus …

Biomolecular activity of cryptococcus during cryptococcosis: A review of molecular interactions of cryptococcus with human immune system and blood-brain-barrier

J Julian, R Adawiyah, S Wahdini - African Journal of Infectious Diseases, 2024 - ajol.info
Global mycosis is still a problem. One of these is the cryptococcal disease. A systemic
mycosis brought on by Cryptococcus is called cryptococcosis. Host immunological …

Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformans

CJ Crawford, L Liporagi-Lopes, C Coelho… - bioRxiv, 2024 - biorxiv.org
Cryptococcus neoformans is a fungus classified by the World Health Organization as a
critically important pathogen, posing a significant threat to immunocompromised individuals …

The buoyancy of cryptococcal cells and its implications for transport and persistence of Cryptococcus in aqueous environments

IA Jimenez, PR Stempinski, Q Dragotakes… - bioRxiv, 2024 - biorxiv.org
Cryptococcus is a genus of saprophytic fungi with global distribution. Two species
complexes, C. neoformans and C. gattii, pose health risks to humans and animals …

Methods of Cryptococcal Polysaccharide Analysis Using ELISA

MP Wear, SA McConnell, SD Greengo… - … : Methods and Protocols, 2024 - Springer
One of the standard assays for the fungal pathogen Cryptococcus neoformans is the
glucuronoxylomannan (GXM) ELISA. This assay utilizes monoclonal antibodies targeted …