Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …

Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (eg,
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

We report locus-specific disintegration of megabase-scale chromosomal conformations in
brain after neuronal ablation of Setdb1 (also known as Kmt1e; encodes a histone H3 lysine …

Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the
leading genetic risk factor for Early-Onset AD, prematurely presenting the classic …

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …

The protocadherins (Pcdhs), which make up the most diverse group within the cadherin
superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including …

Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease
susceptibility, but maps of this phenomenon using stringent criteria in disease-relevant …

Down syndrome is associated with genome-wide perturbation of gene expression, which
may be mediated by epigenetic changes. We perform an epigenome-wide association study …

The risk of severe outcomes following respiratory tract infections is significantly increased in
individuals over 60 years, especially in those with chronic medical conditions, ie …