Epigenetics is a change in gene expression that is heritable without a change in DNA
sequence itself. This phenomenon is well studied in eukaryotes, particularly in humans for …

Naturally occurring modification of the canonical A, G, C, and T bases can be found in the
DNA of cellular organisms and viruses from all domains of life. Bacterial viruses …

DNA chemical modifications regulate genomic function. We present a framework for
mapping cytosine and adenosine methylation with the Oxford Nanopore Technologies …

Adenine base editors (ABEs) are precise gene-editing agents that convert A: T pairs into G:
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …

Synthetic phosphorothioate (PT) internucleotide linkages, in which a nonbridging oxygen is
replaced by a sulphur atom, share similar physical and chemical properties with …

How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

In light of recent predictions that by 2050, antimicrobial resistance will cause almost 10
million deaths annually, costing the global economy 100 trillion US dollars, the examination …

Chromatin, consisting of deoxyribonucleic acid (DNA) wrapped around histone proteins,
facilitates DNA compaction and allows identical DNA codes to confer many different cellular …

Unabated mining and utilisation of petroleum and petroleum resources and their conversion
to essential fuels and chemicals have drastic environmental consequences, contributing to …

DNA methylation is an important epigenetic mechanism for phenotypic diversification in all
forms of life. We previously described remarkable cell-to-cell heterogeneity in epigenetic …