Atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy (C3G), and paroxysmal
nocturnal hemoglobinuria (PNH) are prototypical disorders of complement dysregulation …

The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …

Glomerulonephritis (GN) refers to a group of renal diseases affecting the glomeruli due to
the damage mediated by immunological mechanisms. A large proportion of the disease …

Membranoproliferative glomerulonephritis (MPGN) is subdivided into immune-complex-
mediated glomerulonephritis (IC-MPGN) and C3 glomerulopathy (C3G). Classically, MPGN …

Endothelial cell injury may contribute to the progression of various glomerular diseases. In
the present study, we examined glomerular capillary injury in acute and chronic glomerular …

The complement cascade is part of the innate immune system whose actions protect hosts
from pathogens. Recent research shows complement involvement in a wide spectrum of …

Background: TAFRO syndrome is a clinical subtype of idiopathic multicentric Castleman
disease (iMCD) that is characterized by thrombocytopenia, anasarca, fever and/or elevated …

Genetic defects in complement regulatory proteins can lead to severe renal diseases,
including atypical hemolytic uremic syndrome and C3 glomerulopathies, and age-related …

Thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly (TAFRO)
syndrome is a rare condition with diverse clinical and pathological characteristics related to …

Aims Due to the paucity of studies focusing on primary glomerulonephritis, the second
commonest cause of end‐stage‐kidney‐disease in most of the developed world, we sought …