Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

Bioprinting, within the emerging field of biofabrication, aims at the fabrication of functional
biomimetic constructs. Different 3D bioprinting techniques have been adapted to bioprint cell …

Brain-inspired computing hardware aims to emulate the structure and working principles of
the brain and could be used to address current limitations in artificial intelligence …

For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …

Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …