Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with …

C Lite, A Guru, M Juliet… - Environmental …, 2022 - Wiley Online Library
Parabens are synthetic antimicrobial compounds used as a preservative for extending the
shelf life of food, pharmaceutical and cosmetic products. The alkyl chain length of the …

Syringol, a wildfire residual methoxyphenol causes cytotoxicity and teratogenicity in zebrafish model

PS Priya, A Guru, R Meenatchi… - Science of The Total …, 2023 - Elsevier
Natural toxicants, particularly methoxy phenols (MPs) generated by wildfire lignin, can
accumulate in the environment, and cause serious health hazards in living organisms …

Big things, small packages: an update on microalgae as sustainable sources of nutraceutical peptides for promoting cardiovascular health

CECC Ejike, TPC Ezeorba, O Ajah… - Global …, 2023 - Wiley Online Library
In 2017, a review of microalgae protein‐derived bioactive peptides relevant in
cardiovascular disease (CVD) management was published. Given the rapid evolution of the …

Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway …

G Sudhakaran, R Rajesh, R Murugan… - Phytotherapy …, 2023 - Wiley Online Library
Polycystic ovarian syndrome (PCOS) is a hormonal disorder that causes enlargement of
ovaries and follicular maturation arrest, which lacks efficient treatment. N2, a semi‐natural …

Lipid-lowering and antioxidant activity of RF13 peptide from vacuolar protein sorting-associated protein 26B (VPS26B) by modulating lipid metabolism and oxidative …

A Guru, M Velayutham, J Arockiaraj - International Journal of Peptide …, 2022 - Springer
Obesity is one of the major contributing factors responsible for the onset of various metabolic
syndrome. In obesity-related metabolic syndrome, increased oxidative stress in accumulated …

Pro-inflammatory cytokine molecules from Boswellia serrate suppresses lipopolysaccharides induced inflammation demonstrated in an in-vivo zebrafish larval model

NSS Siddhu, A Guru, RC Satish Kumar… - Molecular Biology …, 2022 - Springer
Background Boswellia serrate is an ancient and highly valued ayurvedic herb. Its extracts
have been used in medicine for centuries to treat a wide variety of chronic inflammatory …

Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection

A Guru, G Sudhakaran, M Velayutham… - … and Physiology Part C …, 2022 - Elsevier
This study investigates the therapeutic activity of daidzein, an isoflavone that occurs
naturally in plants and herbs, against gentamicin-induced nephrotoxicity in Madin-Darby …

Protective effect of morin by targeting mitochondrial reactive oxygen species induced by hydrogen peroxide demonstrated at a molecular level in MDCK epithelial cells

PK Issac, M Velayutham, A Guru, G Sudhakaran… - Molecular Biology …, 2022 - Springer
Background The development of diabetic nephropathy is aided by the presence of oxidative
stress. Morin, a natural flavonoid molecule, has been shown to have antioxidant and anti …

Copper sulfate induced toxicological impact on in-vivo zebrafish larval model protected due to acacetin via anti-inflammatory and glutathione redox mechanism

M Singh, A Guru, G Sudhakaran… - … and Physiology Part C …, 2022 - Elsevier
Copper sulfate (CuSO 4) as industrial effluent is intentionally or unintentionally released into
water bodies and accumulates in the fish. Because of its numerous applications, CuSO 4 …

Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from …

A Guru, J Arockiaraj - Journal of Biochemical and Molecular …, 2023 - Wiley Online Library
Humans are exposed to obesity causing Bisphenol A in various ways, especially through
diet and food containers. Bioactive peptides are already reported to have antioxidant …