Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - Signal transduction and …, 2019 - nature.com
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
Roles and regulations of TET enzymes in solid tumors
The mechanisms governing the methylome profile of tumor suppressors and oncogenes
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …
Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation
L Chen, B Jiang, C Zhong, J Guo, L Zhang… - …, 2018 - academic.oup.com
Freeze-dried black raspberry (BRB) powder is considered as a potential cancer
chemopreventive agent. In this study, we fed azoxymethane (AOM)/dextran sodium sulfate …
chemopreventive agent. In this study, we fed azoxymethane (AOM)/dextran sodium sulfate …
Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers
Promoter CpG methylation is a fundamental regulatory process of gene expression. TET
proteins are active CpG demethylases converting 5-methylcytosine to 5 …
proteins are active CpG demethylases converting 5-methylcytosine to 5 …
Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer
C Xue, Y Zhao, L Li - Biomarker Research, 2020 - Springer
As an important posttranscriptional modification of RNA, 5-methylcytosine (m 5 C) has
attracted increasing interest recently, with accumulating evidence suggesting the …
attracted increasing interest recently, with accumulating evidence suggesting the …
Post-transcriptional regulation by cytosine-5 methylation of RNA
The recent advent of high-throughput sequencing technologies coupled with RNA
modifications detection methods has allowed the detection of RNA modifications at single …
modifications detection methods has allowed the detection of RNA modifications at single …
[HTML][HTML] A positive feedback loop of TET3 and TGF-β1 promotes liver fibrosis
Y Xu, X Sun, R Zhang, T Cao, SY Cai, JL Boyer… - Cell reports, 2020 - cell.com
Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling
in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic …
in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic …
TET2 in normal and malignant hematopoiesis
RL Bowman, RL Levine - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
The ten-eleven translocation (TET) family of enzymes were originally cloned from the
translocation breakpoint of t (10; 11) in infant acute myeloid leukemia (AML) with …
translocation breakpoint of t (10; 11) in infant acute myeloid leukemia (AML) with …
TETology: epigenetic mastermind in action
Cytosine methylation is a well-explored epigenetic modification mediated by DNA
methyltransferases (DNMTs) which are considered “methylation writers”; cytosine …
methyltransferases (DNMTs) which are considered “methylation writers”; cytosine …
[HTML][HTML] The FENDRR/miR-214-3P/TET2 axis affects cell malignant activity via RASSF1A methylation in gastric cancer
Z He, X Wang, C Huang, Y Gao, C Yang… - American journal of …, 2018 - ncbi.nlm.nih.gov
To explore the effect of fetal-lethal non-coding developmental regulatory RNA (FENDRR) in
the initiation and progression of gastric cancer (GC). We detected the levels of FENDRR …
the initiation and progression of gastric cancer (GC). We detected the levels of FENDRR …