A patient in status epilepticus has continuous or rapidly repeating seizures. Although the
danger of this pattern of seizure activity has been recognized since antiquity, our …

Initially thought to be useful only to reach tissues in the immediate vicinity of the CSF
circulatory system, CSF circulation is now increasingly viewed as a viable pathway to deliver …

Consulta preanestésica Una sala de pre-anestesia por área quirúrgica Salas de
recuperación postanestésica susceptible de recibir pacientes de quirófanos contiguos …

Objective: To compare the safety and efficacy of midazolam given intranasally with
diazepam given intravenously in the treatment of children with prolonged febrile seizures …

Midazolam is a 1, 4‐benzodiazepine derivative with a unique chemical structure: depending
on environmental pH, the drug can produce highly water‐soluble salts (pH< 4) or exist in …

Aims For a given passively‐distributed lipophilic drug, the extent of in vivo distribution
(pharmacokinetic volume of distribution, Vd) in obese individuals increases in relation to the …

For drugs that directly act on targets in the central nervous system (CNS), sufficient drug
delivery into the brain is a prerequisite for drug action. Systemically administered drugs can …

Seizure clusters must be treated quickly and effectively to prevent progression to prolonged
seizures and status epilepticus. Rescue therapy for seizure clusters has focused on the use …

Benzodiazepines (BZDs) are widely used by heroin users not in treatment, and by patients
in methadone and buprenorphine (BPN) treatment. This review examines the epidemiology …

The present review discusses the available data on the kinetic properties of non-opiate
abused drugs including psychomotor stimulants, hallucinogens and CNS-depressants …