The brain's vasculature is essential for brain health and its dysfunction contributes to the
onset and development of many dementias and neurological disorders. While numerous in …

The cerebral vasculature manages oxygen delivery by adjusting arterial blood in‐flow in the
face of reductions in oxygen availability. Hypoxic cerebral vasodilatation, and the associated …

Cerebral hypoxic vasodilation is poorly understood in humans, which undermines the
development of therapeutics to optimize cerebral oxygen delivery. Across four investigations …

The importance of nitric oxide (NO) in regulating cerebral blood flow (CBF) remains
unresolved, due in part to methodological approaches, which lack a comprehensive …

Hypoglycemia triggers increases in cerebral blood flow (CBF), augmenting glucose supply
to the brain. We have tested whether astrocytes, which can regulate vessel tone, contribute …

Key points Cognitive function depends on adequate cerebrovascular perfusion and control.
However, it is unknown whether acutely‐reduced cerebral blood flow (CBF) impairs …

Key points ATP‐sensitive K+ (KATP) channels mediate hypoxia‐induced cerebral
vasodilatation and hyperperfusion in animals. We tested whether KATP channels blockade …

Pulse wave encephalopathy (PWE) is hypothesised to initiate many forms of dementia,
motivating its identification and risk assessment. As candidate pulsatility based biomarkers …

The brain requires an uninterrupted supply of oxygen and nutrients to support the high
metabolic needs of billions of nerve cells processing information. In low oxygen conditions …

Dramatic post-mortem prostanoid (PG) enzymatic synthesis in the brain causes a significant
artifact during PG analysis. Thus, enzyme deactivation is required for an accurate in situ …