4D flow MRI for non-invasive measurement of blood flow in the brain: a systematic review
AG Morgan, MJ Thrippleton… - Journal of Cerebral …, 2021 - journals.sagepub.com
The brain's vasculature is essential for brain health and its dysfunction contributes to the
onset and development of many dementias and neurological disorders. While numerous in …
onset and development of many dementias and neurological disorders. While numerous in …
Recent insights into mechanisms of hypoxia‐induced vasodilatation in the human brain
JMJR Carr, RL Hoiland, IA Fernandes… - The Journal of …, 2023 - Wiley Online Library
The cerebral vasculature manages oxygen delivery by adjusting arterial blood in‐flow in the
face of reductions in oxygen availability. Hypoxic cerebral vasodilatation, and the associated …
face of reductions in oxygen availability. Hypoxic cerebral vasodilatation, and the associated …
Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S-nitrosothiol mediated signal transduction
RL Hoiland, DB MacLeod, BS Stacey… - Journal of Cerebral …, 2023 - journals.sagepub.com
Cerebral hypoxic vasodilation is poorly understood in humans, which undermines the
development of therapeutics to optimize cerebral oxygen delivery. Across four investigations …
development of therapeutics to optimize cerebral oxygen delivery. Across four investigations …
Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion
KJ Carter, AT Ward, JM Kellawan… - The Journal of …, 2021 - Wiley Online Library
The importance of nitric oxide (NO) in regulating cerebral blood flow (CBF) remains
unresolved, due in part to methodological approaches, which lack a comprehensive …
unresolved, due in part to methodological approaches, which lack a comprehensive …
Astrocyte regulation of cerebral blood flow during hypoglycemia
AR Nippert, PP Chiang… - Journal of Cerebral …, 2022 - journals.sagepub.com
Hypoglycemia triggers increases in cerebral blood flow (CBF), augmenting glucose supply
to the brain. We have tested whether astrocytes, which can regulate vessel tone, contribute …
to the brain. We have tested whether astrocytes, which can regulate vessel tone, contribute …
Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults
Key points Cognitive function depends on adequate cerebrovascular perfusion and control.
However, it is unknown whether acutely‐reduced cerebral blood flow (CBF) impairs …
However, it is unknown whether acutely‐reduced cerebral blood flow (CBF) impairs …
KATP channels modulate cerebral blood flow and oxygen delivery during isocapnic hypoxia in humans
Key points ATP‐sensitive K+ (KATP) channels mediate hypoxia‐induced cerebral
vasodilatation and hyperperfusion in animals. We tested whether KATP channels blockade …
vasodilatation and hyperperfusion in animals. We tested whether KATP channels blockade …
[HTML][HTML] Measuring global cerebrovascular pulsatility transmission using 4D flow MRI
Pulse wave encephalopathy (PWE) is hypothesised to initiate many forms of dementia,
motivating its identification and risk assessment. As candidate pulsatility based biomarkers …
motivating its identification and risk assessment. As candidate pulsatility based biomarkers …
On the mechanisms of brain blood flow regulation during hypoxia
A Mascarenhas, A Braga… - The Journal of …, 2024 - Wiley Online Library
The brain requires an uninterrupted supply of oxygen and nutrients to support the high
metabolic needs of billions of nerve cells processing information. In low oxygen conditions …
metabolic needs of billions of nerve cells processing information. In low oxygen conditions …
[HTML][HTML] A simplified method for preventing post-mortem alterations of brain prostanoids for true in situ level quantification
D Besch, DR Seeger, B Schofield, SA Golovko… - Journal of Lipid …, 2024 - Elsevier
Dramatic post-mortem prostanoid (PG) enzymatic synthesis in the brain causes a significant
artifact during PG analysis. Thus, enzyme deactivation is required for an accurate in situ …
artifact during PG analysis. Thus, enzyme deactivation is required for an accurate in situ …