To elucidate principles operating in native biological systems and to develop novel
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …

It is likely that most vertebrate genes are associated with 'HTF islands'—DNA sequences in
which CpG is abundant and non-methylated. Highly tissue-specific genes, though, usually …

Here we report that increased pup licking and grooming (LG) and arched-back nursing
(ABN) by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene …

Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

Methylation of mammalian DNA can lead to repression of transcription and alteration of
chromatin structure. Recent evidence suggests that both effects are the result of an …

MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …

A large body of evidence demonstrates that DNA methylation plays a role in gene regulation
in animal cells. Not only is there a correlation between gene transcription and …

Cytosine methylation within CpG dinucleotides has been implicated in the regulation of
gene expression in vertebrates and, in some cases, has been shown to be causative in …

We have studied the mechanism by which DNA methyiation inhibits transcription both in ceil-
free nuclear extracts and in the living ceil. Repression of transcription in vitro for four different …

Hypermethylation of regulatory sequences at the locus of the pi-class glutathione S-
transferase gene GSTP1 was detected in 20 of 20 human prostatic carcinoma tissue …