[HTML][HTML] Adipose tissue and insulin resistance in obese

B Ahmed, R Sultana, MW Greene - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

E Barati, H Nikzad, M Karimian - Cellular and Molecular Life Sciences, 2020 - Springer
Infertility is a global health problem involving about 15% of couples. Approximately half of
the infertility cases are related to male factors. The oxidative stress, which refers to an …

Intergenerational and transgenerational epigenetic inheritance in animals

MF Perez, B Lehner - Nature cell biology, 2019 - nature.com
Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

[HTML][HTML] Obesity, male infertility, and the sperm epigenome

JR Craig, TG Jenkins, DT Carrell, JM Hotaling - Fertility and sterility, 2017 - Elsevier
Obesity is a growing epidemic and a common problem among reproductive-age men that
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities …

[HTML][HTML] Mitochondrial reactive oxygen species (ROS) production alters sperm quality

R Chianese, R Pierantoni - Antioxidants, 2021 - mdpi.com
Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …

Obesity and male infertility: Mechanisms and management

K Leisegang, P Sengupta, A Agarwal, R Henkel - Andrologia, 2021 - Wiley Online Library
Obesity is considered a global health problem affecting more than a third of the population.
Complications of obesity include cardiovascular diseases, type 2 diabetes mellitus …

Cannabinoid exposure and altered DNA methylation in rat and human sperm

SK Murphy, N Itchon-Ramos, Z Visco, Z Huang… - Epigenetics, 2018 - Taylor & Francis
Little is known about the reproductive effects of paternal cannabis exposure. We evaluated
associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA …

Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta‐analysis

A Salas‐Huetos, L Maghsoumi‐Norouzabad… - Obesity …, 2021 - Wiley Online Library
The present updated systematic review and meta‐analysis aims to summarize the evidence
from published studies with low risk for any important bias (based on methodological quality …

[HTML][HTML] Molecular mechanisms underlying the relationship between obesity and male infertility

F Barbagallo, RA Condorelli, LM Mongioì… - Metabolites, 2021 - mdpi.com
In recent decades, the worldwide prevalence of obesity has risen dramatically and is
currently estimated to be around 20%. Obesity is linked to an increased risk of comorbidities …

[HTML][HTML] Obesity, a serious etiologic factor for male subfertility in modern society

Y Liu, Z Ding - Reproduction, 2017 - rep.bioscientifica.com
Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder
resulting from behavioral, environmental and heritable causes. Obesity increases the risks of …