Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …

Complement as a target in COVID-19? | Nature Reviews Immunology Skip to main content
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It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can
directly infect human kidney, thus leading to acute kidney injury (AKI). Here, we perform a …

We suggest the use of MicroCLOTS (microvascular COVID-19 lung vessels obstructive
thromboinflammatory syndrome) as a new name for severe pulmonary coronavirus disease …

Acute respiratory distress syndrome (ARDS) is a devastating clinical manifestation of COVID-
19 pneumonia and is mainly based on an immune-driven pathology. Mounting evidence …

The novel coronavirus disease COVID-19 originates in the lungs, but it may extend to other
organs, causing, in severe cases, multiorgan damage, including cardiac injury and acute …

Growing clinical evidence has implicated complement as a pivotal driver of COVID-19
immunopathology. Deregulated complement activation may fuel cytokine-driven hyper …

Abstract Development of proteolysis targeting chimeras (PROTACs) is emerging as a
promising strategy for targeted protein degradation. However, the drug development using …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …