Primary cilia are specialized sensory organelles that protrude from the apical surface of most
cell types. Over the past two decades, they have been found to play important roles in tissue …

The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …

WNT ligands induce Ca2+ signalling on target cells. PKD1 (polycystin 1) is considered an
orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2) …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Background Bilateral symmetry during vertebrate development is broken at the left-right
organizer (LRO) by ciliary motility and the resultant directional flow of extracellular fluid …

Abstract Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse
Ca2+ signaling pathways. Malfunctioning Ca2+ regulation in PC2 causes autosomal …

The most severe form of autosomal dominant polycystic kidney disease occurs in patients
with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic …

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited
nephropathy responsible for 4%–10% of end-stage renal disease cases. Mutations in the …

It is 20 years since the identification of PKD1, the major gene mutated in autosomal
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …

Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are
unknown. Here, we identify a mechanosensitive (MS) K+ current (I Kmech) that governs …