Oxaliplatin was the first platinum drug with proven activity against colorectal tumors,
becoming a standard in the management of this malignancy. It is also considered for the …

Advances in genomics, proteomics and molecular pathology have generated many
candidate biomarkers with potential clinical value. Their use for cancer staging and …

CpG island hypermethylation and global genomic hypomethylation are common epigenetic
features of cancer cells. Less attention has been focused on histone modifications in cancer …

Cancer is widely perceived as a heterogeneous group of disorders with markedly different
biological properties, which are caused by a series of clonally selected genetic changes in …

The faithful execution of biological processes requires a precise and carefully orchestrated
set of steps that depend on the proper spatial and temporal expression of genes. Here we …

Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …

Transformation of a normal cell to a malignant one requires phenotypic changes often
associated with each of the initiation, promotion and progression phases of the carcinogenic …

Cancer cells exhibit alterations in histone modification patterns at individual genes and
globally at the level of single nuclei in individual cells. We demonstrated previously that …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …

Epigenetics refers to the study of heritable changes in gene expression that occur without a
change in DNA sequence. Research has shown that epigenetic mechanisms provide an" …