One of the hallmarks of cancer is aberrant DNA methylation, which is associated with
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …

ABSTRACT DNA methylation is integral to normal development and disease processes.
However, the genomic distribution of methylated sequences—the methylome—is poorly …

Uveal melanoma (UM) is an aggressive intra-ocular cancer with a strong tendency to
metastasize. Metastatic UM is associated with mutations in BAP1 and SF3B1, however only …

Azurin is a member of a group of copper‐containing redox proteins called cupredoxins.
Different cupredoxins are produced by different aerobic bacteria as agents of electron …

DNA methylation is one of the key epigenetic modifications of DNA that results from the
enzymatic addition of a methyl group at the fifth carbon of the cytosine base. It plays a crucial …

The increasingly evident limitations of target-selective cancer therapy has stimulated a flurry
of ideas for overcoming the development of resistance and recurrence–the near universal …

Purpose: Irinotecan is used in the first-line treatment of metastatic colorectal cancer. The
UGT1A1-metabolizing enzyme, expressed in liver and colon, is primarily involved in the …

The recent approval of azacitidine (Vidaza®), decitabine (Dacogen®) and vorinostat
(Zolinza™) for myelodysplastic syndrome and cutaneous T-cell lymphoma has led to a wave …

This review focuses on the period from January 2004 to December 2005. Nearly 5000
papers and 500 reviews on capillary electrophoresis are listed in SciFinder for this period …

The observation that cancer cells suffer profound alterations in the DNA methylation profile,
with functional consequences in the activity of key genes, together with the recognition that …