Independent methylome-wide association studies of schizophrenia detect consistent case–control differences

RF Chan, AA Shabalin, C Montano… - Schizophrenia …, 2020 - academic.oup.com
Methylome-wide association studies (MWASs) are promising complements to sequence
variation studies. We used existing sequencing-based methylation data, which assayed the …

Dopamine and working memory: genetic variation, stress and implications for mental health

K Klaus, K Pennington - Processes of Visuospatial Attention and Working …, 2019 - Springer
At the molecular level, the neurotransmitter dopamine (DA) is a key regulatory component of
executive function in the prefrontal cortex (PFC) and dysfunction in dopaminergic (DAergic) …

Genome-wide methylation analysis of treatment resistant schizophrenia

V De Luca, Z Chaudhary, N Al-Chalabi, J Qian… - Journal of Neural …, 2023 - Springer
Various studies have investigated the relationship between genetic polymorphisms of
antipsychotic drug-metabolizing agents and drug response. DNA methylation is a form of …

[HTML][HTML] SLC38A10 knockout mice display a decreased body weight and an increased risk-taking behavior in the open field test

FA Lindberg, K Nordenankar… - Frontiers in Behavioral …, 2022 - frontiersin.org
The solute carrier 38 family (SLC38) is a family of 11 members. The most common substrate
among these are alanine and glutamine, and members are present in a wide range of …

[HTML][HTML] Using openly accessible resources to strengthen causal inference in epigenetic epidemiology of neurodevelopment and mental health

E Walton, CL Relton, D Caramaschi - Genes, 2019 - mdpi.com
The recent focus on the role of epigenetic mechanisms in mental health has led to several
studies examining the association of epigenetic processes with psychiatric conditions and …

Integrated genome-wide methylation and expression analyses provide predictors of diagnosis and early response to antidepressant in panic disorder

Z Zou, Y Zhang, Y Huang, J Wang, W Min… - Journal of Affective …, 2023 - Elsevier
Background We investigated differentially methylated and expressed genes between panic
disorder (PD) and healthy controls (HCs) to determine whether DNA methylation and …

[HTML][HTML] Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya

H Eichenauer, S Fischer, E Gardini, S Onsongo… - Clinical …, 2024 - Springer
Background Stress during pregnancy can lead to adverse maternal and infant health
outcomes through epigenetic changes in the hypothalamic–pituitary–adrenal axis. Among …

[HTML][HTML] Subjective mental health, incidence of depressive symptoms in later life, and the role of epigenetics: results from two longitudinal cohort studies

L Perna, Y Zhang, PR Matias-Garcia, KH Ladwig… - Translational …, 2020 - nature.com
The role of self-perceived general health in predicting morbidity and mortality among older
people is established. The predictive value of self-perceived mental health and of its …

Cortical cellular diversity and development in schizophrenia

AJ Price, AE Jaffe, DR Weinberger - Molecular psychiatry, 2021 - nature.com
While a definitive understanding of schizophrenia etiology is far from current reality, an
increasing body of evidence implicates perturbations in early development that alter the …

Urine 5MedC, a marker of DNA methylation, in the progression of chronic kidney disease

A Onishi, H Sugiyama, M Kitagawa… - Disease …, 2019 - Wiley Online Library
Background. Alterations in DNA methylation may be involved in disease progression in
patients with chronic kidney disease (CKD). Recent studies have suggested that 5‐methyl …