Neutrophil-specific genes are abundant in PBMC microarrays from lupus patients because
of the presence of low-density granulocytes (LDGs) in mononuclear cell fractions. The …

The normal microflora of the skin includes staphylococcal species that will induce
inflammation when present below the dermis but are tolerated on the epidermal surface …

This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

We have discovered a distinct mature B-cell subset that accumulates with age, which we
have termed age-associated B cells. These cells comprise up to 30% of mature B cells by 22 …

Summary Primary Sjögren Syndrome (pSS) is an autoimmune disease associated with an
increased risk of lymphoma. Lymphomas complicating pSS are mostly low‐grade B cell non …

Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of
antiviral defense but can cause autoimmunity if misregulated. Cytosolic DNA detection …

Introduction• TLR signalling• Endogenous TLR ligands• Biological significance of signalling
triggered by endogenous TLR ligands‐Ischemia and reperfusion injury‐Tissue repair and …

The interferon-regulatory factor (IRF) family of transcription factors was initially found to be
involved in the induction of genes that encode type I interferons. IRFs have now been shown …

Dendritic cell (DC) responses to extracellular self-DNA and self-RNA are prevented by the
endosomal seclusion of nucleic acid–recognizing Toll-like receptors (TLRs). In psoriasis …

Signalling through the B cell receptor (BCR) is central to the development and maintenance
of B cells. In light of the numerous proliferative and survival pathways activated downstream …