A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs
Neutrophil-specific genes are abundant in PBMC microarrays from lupus patients because
of the presence of low-density granulocytes (LDGs) in mononuclear cell fractions. The …
of the presence of low-density granulocytes (LDGs) in mononuclear cell fractions. The …
[HTML][HTML] Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury
The normal microflora of the skin includes staphylococcal species that will induce
inflammation when present below the dermis but are tolerated on the epidermal surface …
inflammation when present below the dermis but are tolerated on the epidermal surface …
[图书][B] Fundamental immunology
WE Paul - 2012 - books.google.com
This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …
A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
Y Hao, P O'Neill, MS Naradikian… - Blood, The Journal …, 2011 - ashpublications.org
We have discovered a distinct mature B-cell subset that accumulates with age, which we
have termed age-associated B cells. These cells comprise up to 30% of mature B cells by 22 …
have termed age-associated B cells. These cells comprise up to 30% of mature B cells by 22 …
Sjögren syndrome‐associated lymphomas: an update on pathogenesis and management
G Nocturne, X Mariette - British journal of haematology, 2015 - Wiley Online Library
Summary Primary Sjögren Syndrome (pSS) is an autoimmune disease associated with an
increased risk of lymphoma. Lymphomas complicating pSS are mostly low‐grade B cell non …
increased risk of lymphoma. Lymphomas complicating pSS are mostly low‐grade B cell non …
[HTML][HTML] Trex1 prevents cell-intrinsic initiation of autoimmunity
DB Stetson, JS Ko, T Heidmann, R Medzhitov - Cell, 2008 - cell.com
Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of
antiviral defense but can cause autoimmunity if misregulated. Cytosolic DNA detection …
antiviral defense but can cause autoimmunity if misregulated. Cytosolic DNA detection …
Endogenous toll‐like receptor ligands and their biological significance
L Yu, L Wang, S Chen - Journal of cellular and molecular …, 2010 - Wiley Online Library
Introduction• TLR signalling• Endogenous TLR ligands• Biological significance of signalling
triggered by endogenous TLR ligands‐Ischemia and reperfusion injury‐Tissue repair and …
triggered by endogenous TLR ligands‐Ischemia and reperfusion injury‐Tissue repair and …
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
K Honda, T Taniguchi - Nature Reviews Immunology, 2006 - nature.com
The interferon-regulatory factor (IRF) family of transcription factors was initially found to be
involved in the induction of genes that encode type I interferons. IRFs have now been shown …
involved in the induction of genes that encode type I interferons. IRFs have now been shown …
Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
Dendritic cell (DC) responses to extracellular self-DNA and self-RNA are prevented by the
endosomal seclusion of nucleic acid–recognizing Toll-like receptors (TLRs). In psoriasis …
endosomal seclusion of nucleic acid–recognizing Toll-like receptors (TLRs). In psoriasis …
Targeting pathological B cell receptor signalling in lymphoid malignancies
Signalling through the B cell receptor (BCR) is central to the development and maintenance
of B cells. In light of the numerous proliferative and survival pathways activated downstream …
of B cells. In light of the numerous proliferative and survival pathways activated downstream …