A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs

MF Denny, S Yalavarthi, W Zhao… - The journal of …, 2010 - journals.aai.org
Neutrophil-specific genes are abundant in PBMC microarrays from lupus patients because
of the presence of low-density granulocytes (LDGs) in mononuclear cell fractions. The …

[HTML][HTML] Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

Y Lai, A Di Nardo, T Nakatsuji, A Leichtle, Y Yang… - Nature medicine, 2009 - nature.com
The normal microflora of the skin includes staphylococcal species that will induce
inflammation when present below the dermis but are tolerated on the epidermal surface …

[图书][B] Fundamental immunology

WE Paul - 2012 - books.google.com
This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

Y Hao, P O'Neill, MS Naradikian… - Blood, The Journal …, 2011 - ashpublications.org
We have discovered a distinct mature B-cell subset that accumulates with age, which we
have termed age-associated B cells. These cells comprise up to 30% of mature B cells by 22 …

Sjögren syndrome‐associated lymphomas: an update on pathogenesis and management

G Nocturne, X Mariette - British journal of haematology, 2015 - Wiley Online Library
Summary Primary Sjögren Syndrome (pSS) is an autoimmune disease associated with an
increased risk of lymphoma. Lymphomas complicating pSS are mostly low‐grade B cell non …

[HTML][HTML] Trex1 prevents cell-intrinsic initiation of autoimmunity

DB Stetson, JS Ko, T Heidmann, R Medzhitov - Cell, 2008 - cell.com
Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of
antiviral defense but can cause autoimmunity if misregulated. Cytosolic DNA detection …

Endogenous toll‐like receptor ligands and their biological significance

L Yu, L Wang, S Chen - Journal of cellular and molecular …, 2010 - Wiley Online Library
Introduction• TLR signalling• Endogenous TLR ligands• Biological significance of signalling
triggered by endogenous TLR ligands‐Ischemia and reperfusion injury‐Tissue repair and …

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

K Honda, T Taniguchi - Nature Reviews Immunology, 2006 - nature.com
The interferon-regulatory factor (IRF) family of transcription factors was initially found to be
involved in the induction of genes that encode type I interferons. IRFs have now been shown …

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

D Ganguly, G Chamilos, R Lande, J Gregorio… - Journal of Experimental …, 2009 - rupress.org
Dendritic cell (DC) responses to extracellular self-DNA and self-RNA are prevented by the
endosomal seclusion of nucleic acid–recognizing Toll-like receptors (TLRs). In psoriasis …

Targeting pathological B cell receptor signalling in lymphoid malignancies

RM Young, LM Staudt - Nature reviews Drug discovery, 2013 - nature.com
Signalling through the B cell receptor (BCR) is central to the development and maintenance
of B cells. In light of the numerous proliferative and survival pathways activated downstream …