Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …

Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …

During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous
subclonal populations emerge that drive primary tumor growth, regional spread, distant …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …