Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …
The poor outcome associated with HCC is dramatically changing due to the advent of …
Tumour evolution in hepatocellular carcinoma
AJ Craig, J Von Felden, T Garcia-Lezana… - Nature reviews …, 2020 - nature.com
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically
develops on the background of chronic liver disease and is an aggressive disease with …
develops on the background of chronic liver disease and is an aggressive disease with …
Hepatocellular carcinoma: old friends and new tricks
E Kim, P Viatour - Experimental & molecular medicine, 2020 - nature.com
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and a leading
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis …
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis …
METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST
X Yang, S Zhang, C He, P Xue, L Zhang, Z He, L Zang… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA epigenetic
regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is …
regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is …
WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
Y Chen, C Peng, J Chen, D Chen, B Yang, B He, W Hu… - Molecular cancer, 2019 - Springer
Abstract Background N6-methyladenosine (m6A) methylation, a well-known modification
with new epigenetic functions, has been reported to participate in the tumorigenesis of …
with new epigenetic functions, has been reported to participate in the tumorigenesis of …
Molecular therapies and precision medicine for hepatocellular carcinoma
The global burden of hepatocellular carcinoma (HCC) is increasing and might soon surpass
an annual incidence of 1 million cases. Genomic studies have established the landscape of …
an annual incidence of 1 million cases. Genomic studies have established the landscape of …
Advances in molecular classification and precision oncology in hepatocellular carcinoma
S Rebouissou, JC Nault - Journal of hepatology, 2020 - Elsevier
Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …
RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2
Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional
epigenetic studies have predominantly focused on DNA methylation, histone modifications …
epigenetic studies have predominantly focused on DNA methylation, histone modifications …
Liver injury after SARS‐CoV‐2 vaccination: Features of immune‐mediated hepatitis, role of corticosteroid therapy and outcome
Conclusions SARS‐CoV‐2 vaccination can be associated with liver injury. Corticosteroid
therapy may be beneficial in those with immune‐mediated features or severe hepatitis …
therapy may be beneficial in those with immune‐mediated features or severe hepatitis …
Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets
XY Luo, KM Wu, XX He - Journal of Experimental & Clinical Cancer …, 2021 - Springer
Although hepatocellular carcinoma (HCC) is one of the deadliest health burdens worldwide,
few drugs are available for its clinical treatment. However, in recent years, major …
few drugs are available for its clinical treatment. However, in recent years, major …