Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Tumour evolution in hepatocellular carcinoma

AJ Craig, J Von Felden, T Garcia-Lezana… - Nature reviews …, 2020 - nature.com
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically
develops on the background of chronic liver disease and is an aggressive disease with …

Hepatocellular carcinoma: old friends and new tricks

E Kim, P Viatour - Experimental & molecular medicine, 2020 - nature.com
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and a leading
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis …

METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

X Yang, S Zhang, C He, P Xue, L Zhang, Z He, L Zang… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA epigenetic
regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is …

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

Y Chen, C Peng, J Chen, D Chen, B Yang, B He, W Hu… - Molecular cancer, 2019 - Springer
Abstract Background N6-methyladenosine (m6A) methylation, a well-known modification
with new epigenetic functions, has been reported to participate in the tumorigenesis of …

Molecular therapies and precision medicine for hepatocellular carcinoma

JM Llovet, R Montal, D Sia, RS Finn - Nature reviews Clinical oncology, 2018 - nature.com
The global burden of hepatocellular carcinoma (HCC) is increasing and might soon surpass
an annual incidence of 1 million cases. Genomic studies have established the landscape of …

Advances in molecular classification and precision oncology in hepatocellular carcinoma

S Rebouissou, JC Nault - Journal of hepatology, 2020 - Elsevier
Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

M Chen, L Wei, CT Law, FHC Tsang, J Shen… - Hepatology, 2018 - journals.lww.com
Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional
epigenetic studies have predominantly focused on DNA methylation, histone modifications …

Liver injury after SARS‐CoV‐2 vaccination: Features of immune‐mediated hepatitis, role of corticosteroid therapy and outcome

C Efe, AV Kulkarni, BT Beretta‐Piccoli, B Magro… - Hepatology, 2022 - journals.lww.com
Conclusions SARS‐CoV‐2 vaccination can be associated with liver injury. Corticosteroid
therapy may be beneficial in those with immune‐mediated features or severe hepatitis …

Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets

XY Luo, KM Wu, XX He - Journal of Experimental & Clinical Cancer …, 2021 - Springer
Although hepatocellular carcinoma (HCC) is one of the deadliest health burdens worldwide,
few drugs are available for its clinical treatment. However, in recent years, major …