Epigenetics in hepatocellular carcinoma
GP Nagaraju, B Dariya, P Kasa, S Peela… - Seminars in cancer …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC …
has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC …
Liver cancer cell of origin, molecular class, and effects on patient prognosis
Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …
Identification of an immune-specific class of hepatocellular carcinoma, based on molecular features
Background & aims Agents that induce an immune response against tumors by altering T-
cell regulation have increased survival times of patients with advanced-stage tumors, such …
cell regulation have increased survival times of patients with advanced-stage tumors, such …
Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis
R Pinyol, S Torrecilla, H Wang, C Montironi… - Journal of …, 2021 - Elsevier
Background and Aims Non-alcoholic steatohepatitis (NASH)-related hepatocellular
carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We …
carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We …
Mechanisms of HBV-induced hepatocellular carcinoma
M Levrero, J Zucman-Rossi - Journal of hepatology, 2016 - Elsevier
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
[PDF][PDF] Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is a progressive, inflammatory form of fatty liver
disease. It is the most rapidly rising risk factor for the development of hepatocellular …
disease. It is the most rapidly rising risk factor for the development of hepatocellular …
Genetic landscape and biomarkers of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …
mortality has increased in Western populations, with a minority of patients diagnosed at …
Sublethal necroptosis signaling promotes inflammation and liver cancer
M Vucur, A Ghallab, AT Schneider, A Adili, M Cheng… - Immunity, 2023 - cell.com
It is currently not well known how necroptosis and necroptosis responses manifest in vivo.
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …
Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences
S Moran, C Arribas, M Esteller - Epigenomics, 2016 - Taylor & Francis
Aim: DNA methylation is the best known epigenetic mark. Cancer and other pathologies
show an altered DNA methylome. However, delivering complete DNA methylation maps is …
show an altered DNA methylome. However, delivering complete DNA methylation maps is …
Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma
Background & Aims Cholangiocarcinoma (CCA), a deadly malignancy of the bile ducts, can
be classified based on its anatomical location into either intrahepatic (iCCA) or extrahepatic …
be classified based on its anatomical location into either intrahepatic (iCCA) or extrahepatic …