Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma
A Muhammed, A D'Alessio, A Enica… - Expert Review of …, 2022 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) is the most common primary liver cancer and
fourth-leading cause of cancer death. While drug discovery to improve disease survival was …
fourth-leading cause of cancer death. While drug discovery to improve disease survival was …
Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent …
Y Zhou, Z Yin, B Hou, M Yu, R Chen… - Cancer management …, 2019 - Taylor & Francis
Background: N6-methyladenosine (m6A) is the most prevalent modification of mammalian
RNA. Emerging evidence suggest that m6A has critical roles in multiple biological activities …
RNA. Emerging evidence suggest that m6A has critical roles in multiple biological activities …
Fucoidan elevates microRNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocellular carcinoma cells
MD Yan, CJ Yao, JM Chow, CL Chang, PA Hwang… - Marine Drugs, 2015 - mdpi.com
Accumulating evidence has revealed that fucoidan exhibits anti-tumor activities by arresting
cell cycle and inducing apoptosis in many types of cancer cells including hepatocellular …
cell cycle and inducing apoptosis in many types of cancer cells including hepatocellular …
Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis
J George, M Tsuchishima, M Tsutsumi - Cell death & disease, 2019 - nature.com
Hepatic fibrosis is marked by excessive synthesis and deposition of connective tissue
proteins, especially interstitial collagens in the extracellular matrix of the liver. It is a result of …
proteins, especially interstitial collagens in the extracellular matrix of the liver. It is a result of …
Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers
J Cheng, D Wei, Y Ji, L Chen, L Yang, G Li, L Wu… - Genome medicine, 2018 - Springer
Background Hepatocellular carcinoma (HCC) is the one of the most common cancers and
lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and …
lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and …
Methodological challenges in constructing DNA methylation risk scores
Polygenic approaches often access more variance of complex traits than is possible by
single variant approaches. For genotype data, genetic risk scores (GRS) are widely used for …
single variant approaches. For genotype data, genetic risk scores (GRS) are widely used for …
Unique genomic profile of fibrolamellar hepatocellular carcinoma
Background & Aims Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic
cancer that develops in children and young adults without cirrhosis. Little is known about its …
cancer that develops in children and young adults without cirrhosis. Little is known about its …
Unraveling the Significance of EPH/Ephrin Signaling in Liver Cancer: Insights into Tumor Progression and Therapeutic Implications
Simple Summary This narrative literature review delves into the role of EPH/ephrin signaling
in liver cancer and its implications for tumor progression and potential therapeutic strategies …
in liver cancer and its implications for tumor progression and potential therapeutic strategies …
DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsies
E Gonçalves, M Gonçalves-Reis, JB Pereira-Leal… - Scientific Reports, 2022 - nature.com
Hepatocellular carcinoma (HCC) is amongst the cancers with highest mortality rates and is
the most common malignancy of the liver. Early detection is vital to provide the best …
the most common malignancy of the liver. Early detection is vital to provide the best …
Copy-number alteration burden differentially impacts immune profiles and molecular features of hepatocellular carcinoma
L Bassaganyas, R Pinyol, R Esteban-Fabró… - Clinical Cancer …, 2020 - AACR
Purpose: Chromosomal instability is a hallmark of cancer that results in broad and focal copy-
number alterations (CNAs), two events associated with distinct molecular, immunologic, and …
number alterations (CNAs), two events associated with distinct molecular, immunologic, and …