Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma

A Muhammed, A D'Alessio, A Enica… - Expert Review of …, 2022 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) is the most common primary liver cancer and
fourth-leading cause of cancer death. While drug discovery to improve disease survival was …

Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent …

Y Zhou, Z Yin, B Hou, M Yu, R Chen… - Cancer management …, 2019 - Taylor & Francis
Background: N6-methyladenosine (m6A) is the most prevalent modification of mammalian
RNA. Emerging evidence suggest that m6A has critical roles in multiple biological activities …

Fucoidan elevates microRNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocellular carcinoma cells

MD Yan, CJ Yao, JM Chow, CL Chang, PA Hwang… - Marine Drugs, 2015 - mdpi.com
Accumulating evidence has revealed that fucoidan exhibits anti-tumor activities by arresting
cell cycle and inducing apoptosis in many types of cancer cells including hepatocellular …

Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis

J George, M Tsuchishima, M Tsutsumi - Cell death & disease, 2019 - nature.com
Hepatic fibrosis is marked by excessive synthesis and deposition of connective tissue
proteins, especially interstitial collagens in the extracellular matrix of the liver. It is a result of …

Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

J Cheng, D Wei, Y Ji, L Chen, L Yang, G Li, L Wu… - Genome medicine, 2018 - Springer
Background Hepatocellular carcinoma (HCC) is the one of the most common cancers and
lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and …

Methodological challenges in constructing DNA methylation risk scores

A Hüls, D Czamara - Epigenetics, 2020 - Taylor & Francis
Polygenic approaches often access more variance of complex traits than is possible by
single variant approaches. For genotype data, genetic risk scores (GRS) are widely used for …

Unique genomic profile of fibrolamellar hepatocellular carcinoma

H Cornella, C Alsinet, S Sayols, Z Zhang, K Hao… - Gastroenterology, 2015 - Elsevier
Background & Aims Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic
cancer that develops in children and young adults without cirrhosis. Little is known about its …

Unraveling the Significance of EPH/Ephrin Signaling in Liver Cancer: Insights into Tumor Progression and Therapeutic Implications

SP Papadakos, IE Stergiou, N Gkolemi, K Arvanitakis… - Cancers, 2023 - mdpi.com
Simple Summary This narrative literature review delves into the role of EPH/ephrin signaling
in liver cancer and its implications for tumor progression and potential therapeutic strategies …

DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsies

E Gonçalves, M Gonçalves-Reis, JB Pereira-Leal… - Scientific Reports, 2022 - nature.com
Hepatocellular carcinoma (HCC) is amongst the cancers with highest mortality rates and is
the most common malignancy of the liver. Early detection is vital to provide the best …

Copy-number alteration burden differentially impacts immune profiles and molecular features of hepatocellular carcinoma

L Bassaganyas, R Pinyol, R Esteban-Fabró… - Clinical Cancer …, 2020 - AACR
Purpose: Chromosomal instability is a hallmark of cancer that results in broad and focal copy-
number alterations (CNAs), two events associated with distinct molecular, immunologic, and …