Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

In the past decade, assays that profile different aspects of the epigenome have grown
exponentially in number and variation. However, standard guidelines for researchers to …

Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of
HOXA genes in pediatric acute lymphoblastic leukemia - PMC Back to Top Skip to main content …

Individuals with type 2 diabetes (T2D) display vascular insulin resistance and decreased
nitric oxide production leading to vasoconstriction and atherosclerosis. Soluble factors such …

Epigenetics refers to nucleotide sequence-independent events, and heritable changes,
including DNA methylation and histone modification (as the two main processes) …

Background and propose Changes in DNA methylation are associated with changes in
somatic cell fate without the alteration of coding sequences. In addition to its use as a …

Environmental Epigenomics is a developing field to study the epigenetic effect on human
health from exposure to environmental factors. Endocrine disrupting chemicals have been …

Advances in the field of genomics have recently enabled the unprecedented
characterization of the cancer genome, providing novel insight into the molecular …

In drug discovery and development (DDD), the efficacy, safety and cost of new chemical
entities are the main concerns of the pharmaceutical industry. Continuously updated and …

The analysis of cytosine methylation provides a new way to assess and describe epigenetic
regulation at a whole-genome level in many eukaryotes. DNA methylation has a …