Understanding the underlying mechanisms of memory formation and maintenance has been
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Animal models of early postnatal mother–infant interactions have highlighted the importance
of tactile contact for biobehavioral outcomes via the modification of DNA methylation …

Introduction DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …

Background Little is known about the role of DNA methylation (DNAm) epigenetic age
acceleration in cognitive decline. Using a twin study design, we examined whether DNAm …

A single event can cause a life-long memory. Memories physically reside in neurons, and
changes in neuronal gene expression are considered to be central to memory. Early models …

In recent years, a greater understanding has emerged of the role epigenetic mechanisms
play in the brain, not only during development, but also in mature neurons involved in long …

Among the dangers to astronauts engaging in deep space missions such as a Mars
expedition is exposure to radiations that put them at risk for severe cognitive dysfunction …

The formation of long-term memory involves a series of molecular and cellular changes,
including gene transcription, protein synthesis and synaptic plasticity dynamics. Some of …