The rapid increase of omic data has greatly facilitated the investigation of associations
between omic profiles such as DNA methylation (DNAm) and complex traits in large cohorts …

DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …

With the availability of DNA-based molecular markers during early 1980s and that of
sophisticated statistical tools in late 1980s and later, it became possible to identify genomic …

Increasing evidence points to a complex interplay between genes and the environment in
autism spectrum disorder (ASD), including rare de novo mutations in chromatin genes such …

The last decade brought tremendous progress in the field of schizophrenia genetics. As a
result of extensive collaborations and multiple technological advances, we now recognize …

Genome-wide association studies (GWASs) have reported many single nucleotide
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking …

Identification of causal variants and genes underlying genome-wide association study
(GWAS) loci is essential to understand the biology of alcohol use disorder (AUD) and drinks …

Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration,
yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology …

Background Prenatal exposure to infectious or inflammatory insults increases the risk of
neurodevelopmental disorders. Using a well-established mouse model of prenatal viral-like …

Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …