Developments in biological mechanisms and treatments for negative symptoms and cognitive dysfunction of schizophrenia
Q Wu, X Wang, Y Wang, YJ Long, JP Zhao… - Neuroscience Bulletin, 2021 - Springer
The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction
in schizophrenia are the main issues attracting the attention of psychiatrists over the last …
in schizophrenia are the main issues attracting the attention of psychiatrists over the last …
Cell type-specific epigenetic links to schizophrenia risk in the brain
Background The importance of cell type-specific epigenetic variation of non-coding regions
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
Altered expression of histamine signaling genes in autism spectrum disorder
C Wright, JH Shin, A Rajpurohit… - Translational …, 2017 - nature.com
The histaminergic system (HS) has a critical role in cognition, sleep and other behaviors.
Although not well studied in autism spectrum disorder (ASD), the HS is implicated in many …
Although not well studied in autism spectrum disorder (ASD), the HS is implicated in many …
Cannabinoid CB2 receptors are upregulated via bivalent histone modifications and control primary afferent input to the spinal cord in neuropathic pain
Type-2 cannabinoid receptors (CB2, encoded by the Cnr2 gene) are mainly expressed in
immune cells, and CB2 agonists normally have no analgesic effect. However, nerve injury …
immune cells, and CB2 agonists normally have no analgesic effect. However, nerve injury …
Association of a reproducible epigenetic risk profile for schizophrenia with brain methylation and function
Importance Schizophrenia is a severe mental disorder in which epigenetic mechanisms may
contribute to illness risk. Epigenetic profiles can be derived from blood cells, but to our …
contribute to illness risk. Epigenetic profiles can be derived from blood cells, but to our …
Fifty years of research on schizophrenia: the ascendance of the glutamatergic synapse
In 1976, I (JTC) finished my psychiatric residency, received my first National Institutes of
Health grant, opened my laboratory, and took responsibility for the Schizophrenia Outpatient …
Health grant, opened my laboratory, and took responsibility for the Schizophrenia Outpatient …
Microglial contribution to the pathology of neurodevelopmental disorders in humans
R Matuleviciute, ET Akinluyi, TAO Muntslag… - Acta …, 2023 - Springer
Microglia are the brain's resident macrophages, which guide various developmental
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …
[PDF][PDF] Chromosomal inversion polymorphisms shape human brain morphology
The impact of chromosomal inversions on human brain morphology remains underexplored.
We studied 35 common inversions classified from genotypes of 33,018 adults with European …
We studied 35 common inversions classified from genotypes of 33,018 adults with European …
qSVA framework for RNA quality correction in differential expression analysis
RNA sequencing (RNA-seq) is a powerful approach for measuring gene expression levels
in cells and tissues, but it relies on high-quality RNA. We demonstrate here that statistical …
in cells and tissues, but it relies on high-quality RNA. We demonstrate here that statistical …