Brain development has largely been studied through unimodal analysis of neuroimaging
data, providing independent results for structural and functional data. However, structure …

Schizophrenia is a severe neuropsychiatric disorder with core features including
hallucinations, delusions, and cognition deficits. Accumulating evidence has implicated …

Many psychiatric disorders are characterized by a strong sex difference, but the mechanisms
behind sex-bias are not fully understood. DNA methylation plays important roles in …

Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-
ranging domains encompassing multiple transcriptional units, including heritability loci for …

Background DNA methylation (DNAm) is a critical regulator of both development and
cellular identity and shows unique patterns in neurons. To better characterize maturational …

It is estimated that the impact of related genes on the risk of Alzheimer's disease (AD) is
nearly 70%. Identifying candidate causal genes can help treatment and diagnosis. The …

Brain development is guided by the interactions between the genetic blueprint and the
environment. Epigenetic mechanisms, especially DNA methylation, can mediate these …

Abstract Schizophrenia's (SZ's) heritability and familial transmission have been known for
several decades; however, despite the clear evidence for a genetic component, it has been …

Emerging evidence emphasizes the strong impact of regulatory genomic elements in
neurodevelopmental processes and the complex pathways of brain disorders. The present …

Nonrandom chromosomal conformations, including promoter–enhancer loopings that
bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional …