[HTML][HTML] Epigenetics of male infertility: the role of DNA methylation

JC Rotondo, C Lanzillotti, C Mazziotta… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

[HTML][HTML] SARS-CoV-2 infection: new molecular, phylogenetic, and pathogenetic insights. Efficacy of current vaccines and the potential risk of variants

JC Rotondo, F Martini, M Maritati, C Mazziotta… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered
coronavirus responsible for the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 …

[HTML][HTML] Advanced molecular and immunological diagnostic methods to detect SARS-CoV-2 infection

JC Rotondo, F Martini, M Maritati, E Caselli… - Microorganisms, 2022 - mdpi.com
Simple Summary COVID-19 emerged in late 2019 in China and rapidly spread across the
globe. After 2 years, numerous advances have been made. First of all, the preventive …

[HTML][HTML] Cancer biology and molecular genetics of A3 adenosine receptor

C Mazziotta, JC Rotondo, C Lanzillotti, G Campione… - Oncogene, 2022 - nature.com
Abstract A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to
be overexpressed in a large number of cancer types. This receptor plays an important role in …

[HTML][HTML] DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts

A Goyal, J Bauer, J Hey, DN Papageorgiou… - Nature …, 2023 - nature.com
Immunotherapies targeting cancer-specific neoantigens have revolutionized the treatment of
cancer patients. Recent evidence suggests that epigenetic therapies synergize with …

[HTML][HTML] Epigenetic dysregulations in merkel cell polyomavirus-driven merkel cell carcinoma

JC Rotondo, C Mazziotta, C Lanzillotti… - International Journal of …, 2021 - mdpi.com
Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is
the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the …

[HTML][HTML] The role of histone post-translational modifications in merkel cell carcinoma

C Mazziotta, C Lanzillotti, R Gafà, A Touzé… - Frontiers in …, 2022 - frontiersin.org
Merkel Cell Carcinoma (MCC) is a is a rare but highly aggressive form of non–melanoma
skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small …

[HTML][HTML] MicroRNAs modulate signaling pathways in osteogenic differentiation of mesenchymal stem cells

C Mazziotta, C Lanzillotti, MR Iaquinta… - International journal of …, 2021 - mdpi.com
Mesenchymal stem cells (MSCs) have been identified in many adult tissues and they have
been closely studied in recent years, especially in view of their potential use for treating …

Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease

L Penter, Y Liu, JO Wolff, L Yang, L Taing, A Jhaveri… - Blood, 2023 - ashpublications.org
The challenge of eradicating leukemia in patients with acute myelogenous leukemia (AML)
after initial cytoreduction has motivated modern efforts to combine synergistic active …

[HTML][HTML] Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia

J Shao, S Wang, D West-Szymanski, J Karpus… - Scientific Reports, 2022 - nature.com
Abstract Aberrant changes in 5-hydroxymethylcytosine (5hmC) are a unique epigenetic
feature in many cancers including acute myeloid leukemia (AML). However, genome-wide …