Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - Signal transduction and …, 2019 - nature.com
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …
of DNA sequence. It requires interactions cohesively with various enzymes and other …
New concepts in DNA methylation
A Jeltsch, RZ Jurkowska - Trends in biochemical sciences, 2014 - cell.com
The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
Structure and function of mammalian DNA methyltransferases
DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …
regulation, chromatin structure, development and disease. Here, we review the structures …
In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA
methylation patterns in a particular genome context is not well understood. Here, we …
methylation patterns in a particular genome context is not well understood. Here, we …
Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
A Jeltsch, RZ Jurkowska - Nucleic acids research, 2016 - academic.oup.com
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
Origins of human disease: the chrono-epigenetic perspective
ES Oh, A Petronis - Nature Reviews Genetics, 2021 - nature.com
Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …
features that cannot be explained by genetic and environmental factors. However …
DNA methylation inhibitors in cancer: recent and future approaches
This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …
roles, their mechanisms of action and their role in cancer. The description of assays for …
Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration
Mitotic inheritance of the DNA methylome is a challenging task for the maintenance of cell
identity. Whether DNA methylation pattern in different genomic contexts can all be faithfully …
identity. Whether DNA methylation pattern in different genomic contexts can all be faithfully …
Biochemistry and regulation of the protein arginine methyltransferases (PRMTs)
Many key cellular processes can be regulated by the seemingly simple addition of one, or
two, methyl groups to arginine residues by the nine known mammalian protein arginine …
two, methyl groups to arginine residues by the nine known mammalian protein arginine …