Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a
contractile phenotype that maintains the normal vessel structure and function under …

Oxidative stress (OS) refers to the enhancement of oxidation and the decreased of related
antioxidant enzymes activity under pathological conditions, resulting in relatively excess …

Cardiovascular disease is the major cause of death worldwide. The success of medication
and other preventive measures introduced in the last century have not yet halted the …

Increased vascular calcification (VC) is observed in patients with cardiovascular diseases
such as atherosclerosis, diabetes, and chronic kidney disease. VC is divided into three types …

Aortic dissection (AD) is a rare but catastrophic disorder, and associated with significant
morbidity among survivors. This study aimed to target IRE1α-XBP1s pathway …

Autophagy is a well-conserved biological process that maintains homeostasis. Accumulating
evidence has revealed that autophagy plays an important role in various cardiovascular …

Thoracic aortic dissection (TAD) is common but lethal cardiovascular disease with high
mortality. This study aimed to expound whether and how sGC-PRKG1 signaling pathway …

Phenotypic switching of vascular smooth muscle cells is a central process in abdominal
aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7 …