Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of
choline results in the production of trimethylamine (TMA), which, upon absorption by the host …

Environmental changes can induce diversity shifts within ecosystems that affect interactions
between species. Similarly, the development of kidney disease induces shifts within the …

Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary
phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the …

Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular
diseases. We investigated whether increased circulating levels of the gut microbiome …

Near-field electrospinning (NFES) is a micro-or nanofiber production technology based on
jetting molten polymer or polymer solution. Thanks to the programmable collector and …

Aging is associated with declines in cognitive performance, which are mediated in part by
neuroinflammation, characterized by astrocyte activation and higher levels of pro …

The kidneys and heart share functions with the common goal of maintaining homeostasis.
When kidney injury occurs, many compounds, the so-called “uremic retention solutes” or …

Background Emerging evidence demonstrates that gut dysbiosis is implicated in the
pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving …

The gut microbiota plays a pivotal role in the onset and development of diabetes and its
complications. Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite of …

Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …