After fertilization, maternal factors direct development and trigger zygotic genome activation
(ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for …

During the first stages of metazoan development, the genomes of the highly specified sperm
and egg must unite and be reprogrammed to allow for the generation of a new organism …

Bisphenol A (BPA) is a commercially important high production chemical widely used in
epoxy resins and polycarbonate plastics, and is ubiquitous in the environment. Previous …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Zebrafish (Danio rerio) is one of a number of teleost fish species frequently employed in
toxicology. Toxico-genomics determines global transcriptomic responses to chemical …

The spermatozoa and oocyte are very specialized cells which possess the unique ability to
fuse and to produce an embryo. This embryo will develop into a mature organism capable of …

Rapid climate change is placing many marine species at risk of local extinction. Recent
studies show that epigenetic mechanisms (eg DNA methylation, histone modifications) can …

The pyrethroid insecticide permethrin is widely used for agricultural and domestic purposes.
Previous data indicated that it acts as a developmental neurotoxicant and can induce …

Early-life exposure to toxicants could affect health outcomes in adulthood. We determined
the effects of early-life exposure to the organophosphorus flame-retardant tris (1, 3-dichloro …

Altered DNA methylation is pervasively associated with changes in gene expression and
signal transduction after exposure to a wide range of endocrine disrupting chemicals. As a …