[HTML][HTML] Targeting DNA methylation and demethylation in diabetic foot ulcers

JY Deng, XQ Wu, WJ He, X Liao, M Tang… - Journal of Advanced …, 2023 - Elsevier
Background Poor wound healing is a significant complication of diabetes, which is
commonly caused by neuropathy, trauma, deformities, plantar hypertension and peripheral …

5-methylcytosine turnover: Mechanisms and therapeutic implications in cancer

M Turpin, G Salbert - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
DNA methylation at the 5th position of cytosine (5mC) is one of the most studied epigenetic
mechanisms essential for the control of gene expression and for many other biological …

[PDF][PDF] Millennia-long epigenetic fluctuations generate intragenic DNA methylation variance in Arabidopsis populations

A Briffa, E Hollwey, Z Shahzad, JD Moore, DB Lyons… - Cell Systems, 2023 - cell.com
Methylation of CG dinucleotides (mCGs), which regulates eukaryotic genome functions, is
epigenetically propagated by Dnmt1/MET1 methyltransferases. How mCG is established …

[HTML][HTML] Concepts, mechanisms and implications of long-term epigenetic inheritance

E Hollwey, A Briffa, M Howard, D Zilberman - Current Opinion in Genetics & …, 2023 - Elsevier
Many modes and mechanisms of epigenetic inheritance have been elucidated in
eukaryotes. Most of them are relatively short-term, generally not exceeding one or a few …

Methylation in cornea and corneal diseases: a systematic review

Y Xia, K Chen, Q Yang, Z Chen, L Jin, L Zhang… - Cell Death …, 2024 - nature.com
Corneal diseases are among the primary causes of blindness and vision loss worldwide.
However, the pathogenesis of corneal diseases remains elusive, and diagnostic and …

Unified establishment and epigenetic inheritance of DNA methylation through cooperative MET1 activity

A Briffa, E Hollwey, Z Shahzad, JD Moore, DB Lyons… - bioRxiv, 2022 - biorxiv.org
Methylation of CG dinucleotides (mCG), which regulates eukaryotic genome functions, is
epigenetically propagated by Dnmt1/MET1 methyltransferases. How mCG is established …

Genome-wide differential DNA methylomes provide insights into the infertility of triploid oysters

D Sun, H Yu, Q Li - Marine Biotechnology, 2022 - Springer
Chromosomal incompatibility and gene expression changes would affect the development
of polyploid gonad and gamete formation. The role of epigenetics like DNA methylation in …

The Role of Different TET Proteins in Cytosine Demethylation Revealed by Mathematical Modeling

K Kurasz, J Rzeszowska-Wolny, R Oliński, M Foksiński… - Epigenomes, 2024 - mdpi.com
In living cells, some reactions can be conducted by more than one enzyme and sometimes it
is difficult to establish which enzyme is responsible. Such is the case with proteins from the …

[PDF][PDF] MC profiling: a novel approach to analyze DNA methylation heterogeneity in genome-wide bisulfite sequencing data

G De Riso, A Sarnataro, G Scala… - NAR Genomics and …, 2022 - academic.oup.com
DNA methylation is an epigenetic mark implicated in crucial biological processes. Most of
the knowledge about DNA methylation is based on bulk experiments, in which DNA …

Mathematical model of RNA-directed DNA methylation predicts siRNA production in bursts

R Dale, RA Mosher - bioRxiv, 2023 - biorxiv.org
RNA-directed DNA Methylation (RdDM) is a plant-specific de novo methylation pathway that
is responsible for maintenance of asymmetric methylation (CHH, where H= A, T, or G) in …