Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment
from the point of view of medicinal chemistry and drug design, focusing on the mechanism of …

Aberrant activation of AKT disturbs the proliferation, survival and metabolic homeostasis of
various human cancers. Thus, it is critical to understand the upstream signalling pathways …

Cisplatin-related ototoxicity is a critical side effect of chemotherapy and can lead to
irreversible hearing loss. This study aimed to assess the potential effect of the DNA …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

DNA methylation is a major epigenetic modification that is strongly involved in the
physiological control of genome expression. DNA methylation patterns are largely modified …

Recently, despite the great success achieved by the so‐called “magic bullets” in the
treatment of different diseases through a marked and specific interaction with the target of …

DNA methylation is a mammalian epigenetic mark that is involved in defining where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

Background Chimeric antigen receptor (CAR) T cells and immune checkpoint blockades
(ICBs) have made remarkable breakthroughs in cancer treatment, but the efficacy is still …