Epigenetic regulators of DNA cytosine modification: promising targets for Cancer Therapy
Epigenetic modifications are crucial regulators of gene expression that critically impact cell
lineage differentiation, survival, and proliferation, and dysregulations are commonly …
lineage differentiation, survival, and proliferation, and dysregulations are commonly …
Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by …
R Liu, X Wu, X He, R Wang, X Yin, F Zhou, M Ji… - Pharmacology …, 2021 - Elsevier
Long-lasting pain can induce depression, which seriously affects life quality of the patients,
but little is known about the underlying mechanism. Chronic neuropathic pain can modulate …
but little is known about the underlying mechanism. Chronic neuropathic pain can modulate …
Prognostic and therapeutic significance of phosphorylated STAT3 and protein tyrosine phosphatase-6 in peripheral-T cell lymphoma
JJ Han, M O'byrne, MJ Stenson, MJ Maurer… - Blood cancer …, 2018 - nature.com
Peripheral T cell lymphomas (PTCL) is a heterogenous group of non-Hodgkin lymphoma
and many patients remain refractory to the frontline therapy. Identifying new prognostic …
and many patients remain refractory to the frontline therapy. Identifying new prognostic …
Insights into the Inhibitory Mechanisms of the Covalent Drugs for DNMT3A
The perturbations of DNA methyltransferase 3 alpha (DNMT3A) may cause uncontrolled
gene expression, resulting in cancers and tumors. The DNMT inhibitors Azacytidine (AZA) …
gene expression, resulting in cancers and tumors. The DNMT inhibitors Azacytidine (AZA) …
DNA demethylation by 5-aza-2′-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences
Background DNA methylation can be abnormally regulated in human disease and
associated with effects on gene transcription that appear to be causally related to …
associated with effects on gene transcription that appear to be causally related to …
Unraveling the reaction mechanism of enzymatic C5-cytosine methylation of DNA. A combined molecular dynamics and QM/MM study of wild type and Gln119 variant
M. HhaI is a DNA methyltransferase from Haemophilus hemolyticus that catalyzes the
transfer of a methyl group from S-adenosyl-l-methionine (SAM) to the C5 position of a …
transfer of a methyl group from S-adenosyl-l-methionine (SAM) to the C5 position of a …
DNA methyltransferase inhibitors: development and applications
M Lopez, L Halby, PB Arimondo - DNA Methyltransferases-Role and …, 2016 - Springer
As described in previous chapters of this book, DNA methylation is involved in numerous
biological processes, and modulation of the activity of DNA methyltransferases (DNMTs) is a …
biological processes, and modulation of the activity of DNA methyltransferases (DNMTs) is a …
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
K Liu, Y Liu, JL Lau, J Min - Pharmacology & Therapeutics, 2015 - Elsevier
Chromatin structure is dynamically modulated by various chromatin modifications, such as
histone/DNA methylation and demethylation. We have reviewed histone methyltransferases …
histone/DNA methylation and demethylation. We have reviewed histone methyltransferases …
Danhong injection alleviates cardiac fibrosis via preventing the hypermethylation of Rasal1 and Rassf1 in TAC mice
S Li, P Li, W Liu, J Shang, S Qiu, X Li… - Oxidative Medicine …, 2020 - Wiley Online Library
Background/Aim. Danhong injection (DHI) is a Chinese patent drug used for relieving
cardiovascular diseases. Recent studies have suggested that DNA methylation plays a …
cardiovascular diseases. Recent studies have suggested that DNA methylation plays a …
Rational drug design of antineoplastic agents using 3D-QSAR, cheminformatic, and virtual screening approaches
J Vucicevic, K Nikolic… - Current medicinal …, 2019 - ingentaconnect.com
Background: Computer-Aided Drug Design has strongly accelerated the development of
novel antineoplastic agents by helping in the hit identification, optimization, and evaluation …
novel antineoplastic agents by helping in the hit identification, optimization, and evaluation …