Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

The notion that the germ line does not age goes back to the 19th-century ideas of August
Weismann. However, being metabolically active, the germ line accumulates damage and …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

DNA methylation is a repressive epigenetic modification that is essential for development,
exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA …

DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …

DNA methylation plays a critical role in spermatogenesis, as evidenced by the male sterility
of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the …

The majority of gene transcripts generated by RNA polymerase II in mammalian genomes
initiate at CpG island (CGI) promoters,, yet our understanding of their regulation remains …

Background Perturbation of DNA methyltransferases (DNMTs) and of the active DNA
demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases …