Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young
patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes …

Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are
considered attractive sources of pancreatic β cells and islet organoids. Recently, several …

Diabetes mellitus type 1 and type 2 have become a global epidemic with dramatically
increasing incidences. Poorly controlled diabetes is associated with severe life-threatening …

Over the last 4 decades, cell culture techniques have evolved towards the creation of in vitro
multicellular entities that incorporate the three-dimensional complexity of in vivo tissues and …

Background Induced pluripotent stem cells (iPSCs) offer potential to revolutionize
regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells …

Diabetes mellitus is the most common abnormal carbohydrate metabolism disorder affecting
millions of people worldwide. It is characterized by hyperglycemia as a result of ß-cell …

Over the last century, diabetes has been treated with subcutaneous insulin, a discovery that
enabled patients to forego death from hyperglycemia. Despite novel insulin formulations …

Introduction To complement islet transplantation for type1 diabetic patients, cell-based
therapy using pluripotent stem cells such as ES cells and iPS cells is promising. Many …

The limited availability of primary human β-cells/islets and their quality (due to donor
diversity) restrict the development of in vitro models for diabetes research. Human induced …

Over the past decade, there had been progress in the development of cell therapy for insulin-
dependent diabetes. Nevertheless, important hurdles that need to be overcome still remain …