Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

A general approach for heritably altering gene expression has the potential to enable many
discovery and therapeutic efforts. Here, we present CRISPRoff—a programmable epigenetic …

Studies have reported a positive correlation between elevated CD8+ T cells in the tumor
microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T …

Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …

Small cell lung cancer (SCLC) is notorious for its early and frequent metastases, which
contribute to it as a recalcitrant malignancy. To understand the molecular mechanisms …

Mammalian DNA methylation patterns are established by two de novo DNA
methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive …

DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two
important heterochromatin-enriched marks that frequently cooperate in silencing repetitive …