Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation
In mammals, repressive histone modifications such as trimethylation of histone H3 Lys9
(H3K9me3), frequently coexist with DNA methylation, producing a more stable and silenced …
(H3K9me3), frequently coexist with DNA methylation, producing a more stable and silenced …
DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS
Peripheral T-cell lymphomas (PTCLs) are heterogenous T-cell neoplasms often associated
with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A …
with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A …
CRISPR/dCas9 tools: Epigenetic mechanism and application in gene transcriptional regulation
R Cai, R Lv, X Shi, G Yang, J Jin - International Journal of Molecular …, 2023 - mdpi.com
CRISPR/Cas9-mediated cleavage of DNA, which depends on the endonuclease activity of
Cas9, has been widely used for gene editing due to its excellent programmability and …
Cas9, has been widely used for gene editing due to its excellent programmability and …
5mC modification orchestrates choriogenesis and fertilization by preventing prolonged ftz-f1 expression
DNA methylation at the fifth position of cytosine (5-methylcytosine, 5mC) is a crucial
epigenetic modification for regulating gene expression, but little is known about how it …
epigenetic modification for regulating gene expression, but little is known about how it …
Progress and Perspective of CRISPR‐Cas9 Technology in Translational Medicine
R Zheng, L Zhang, R Parvin, L Su, J Chi… - Advanced …, 2023 - Wiley Online Library
Translational medicine aims to improve human health by exploring potential treatment
methods developed during basic scientific research and applying them to the treatment of …
methods developed during basic scientific research and applying them to the treatment of …
Epigenetic modification regulates tumor progression and metastasis through EMT
T Tan, P Shi, MN Abbas, Y Wang… - International …, 2022 - spandidos-publications.com
Epigenetics is the study of heritable molecular determinants that are independent of
phenotypic features. The epigenetic features include DNA methylation, histone …
phenotypic features. The epigenetic features include DNA methylation, histone …
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation
The de novo DNA methyltransferases Dnmt3a and Dnmt3b play crucial roles in
developmental and cellular processes. Their enzymatic activities are stimulated by a …
developmental and cellular processes. Their enzymatic activities are stimulated by a …
Epigenetic Reprogramming in Mice and Humans: From Fertilization to Primordial Germ Cell Development
A Singh, DA Rappolee, DM Ruden - Cells, 2023 - mdpi.com
In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …
to the development of primordial germline cells in a mouse and human embryo are …
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation
Abstract DNA methyltransferase DNMT3A is essential for establishment of mammalian DNA
methylation during development. The R882H DNMT3A is a hotspot mutation in acute …
methylation during development. The R882H DNMT3A is a hotspot mutation in acute …
Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
M Emperle, S Adam, S Kunert, M Dukatz… - Nucleic acids …, 2019 - academic.oup.com
Somatic DNMT3A mutations at R882 are frequently observed in AML patients including the
very abundant R882H, but also R882C, R882P and R882S. Using deep enzymology, we …
very abundant R882H, but also R882C, R882P and R882S. Using deep enzymology, we …