Abstract DNA methyltransferase DNMT3B plays an essential role in establishment of DNA
methylation during embryogenesis. Mutations of DNMT3B are associated with human …

Fetal growth restriction is a pathological condition occurring when the fetus does not reach
the genetically determined growth potential. The etiology of fetal growth restriction is …

DNA methylation plays important roles in determining cellular identity, disease, and
environmental responses, but little is known about the mechanisms that drive methylation …

Dysregulation of the oncogenic transcription factor HOXA9 is a prominent feature for most
aggressive acute myeloid leukemia cases and a strong indicator of poor prognosis in …

The tremendous potential for graphene quantum dots (GQDs) in biomedical applications
has led to growing concerns of their health risks in human beings. However, present studies …

DNA methyltransferases are primary enzymes for cytosine methylation at CpG sites of
epigenetic gene regulation in mammals. De novo methyltransferases DNMT3A and …

Background Diabetes-related osteoporosis (DOP) is a chronic disease caused by the high
glucose environment that induces a metabolic disorder of osteocytes and osteoblast …

DNMT3A mutations play a prominent role in clonal hematopoiesis and myeloid neoplasms
with arginine (R) 882 as a hotspot, however the clinical implications of R882 vs. non-R882 …

DNA interacting enzymes recognize their target sequences embedded in variable flanking
sequence context. The influence of flanking sequences on enzymatic activities of DNA …

DNA methylation at CG sites is important for gene regulation and embryonic development. In
mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone …