Dynamic evolution of de novo DNA methyltransferases in rodent and primate genomes
Transcriptional silencing of retrotransposons via DNA methylation is paramount for
mammalian fertility and reproductive fitness. During germ cell development, most …
mammalian fertility and reproductive fitness. During germ cell development, most …
Transgenerational impaired spermatogenesis with sperm H19 and Gtl2 hypomethylation induced by the endocrine disruptor p, p'-DDE
Y Song, L Yang - Toxicology Letters, 2018 - Elsevier
The hypothesis of fetal origins unraveled that environmental exposures in early life could
alter epigenetic modifications in the male germ-line, increasing the susceptibility to adult …
alter epigenetic modifications in the male germ-line, increasing the susceptibility to adult …
[HTML][HTML] miR-4270 suppresses hepatocellular carcinoma progression by inhibiting DNMT3A-mediated methylation of HGFAC promoter
Q Zou, S Cao - PeerJ, 2023 - peerj.com
Background miR-4270 is a regulatory factor has been linked with the progression of various
cancers, such as nasopharyngeal carcinoma, hepatocellular carcinoma (HCC), and gastric …
cancers, such as nasopharyngeal carcinoma, hepatocellular carcinoma (HCC), and gastric …
[HTML][HTML] Targeting DNA methylation in leukemia, myelodysplastic syndrome, and lymphoma: a potential diagnostic, prognostic, and therapeutic tool
L Kalinkova, A Sevcikova, V Stevurkova… - International Journal of …, 2022 - mdpi.com
DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic
malignancies. The methylation process is controlled by specific DNA methyl transferases …
malignancies. The methylation process is controlled by specific DNA methyl transferases …
Epigenetic mechanisms are behind the regulation of the key genes associated with the osteoblastic differentiation of the mesenchymal stem cells: The role of …
Mesenchymal stem cells (MSCs) are multipotent stem cells and show distinct features such
as capability for self‐renewal and differentiation into several lineages of cells including …
as capability for self‐renewal and differentiation into several lineages of cells including …
[HTML][HTML] Hypermethylation of PRKCZ regulated by E6 inhibits invasion and EMT via Cdc42 in HPV-related head and neck squamous cell carcinoma
HF Wang, J Jiang, JS Wu, M Zhang, X Pang, L Dai… - Cancers, 2022 - mdpi.com
Simple Summary HPV+ and HPV-HNSCC share distinct epigenetic characteristics and
clinicopathological features. The aim of our study was to assess whether DNA methylation …
clinicopathological features. The aim of our study was to assess whether DNA methylation …
Genome-wide DNA methylation signatures are determined by DNMT3A/B sequence preferences
Cytosine methylation is an important epigenetic mark, but how the distinctive patterns of
DNA methylation arise remains elusive. For the first time, we systematically investigated how …
DNA methylation arise remains elusive. For the first time, we systematically investigated how …
Targeting tumor endothelial cells with methyltransferase inhibitors: mechanisms of action and the potential of combination therapy
S Zhou, H Ou, Y Wu, D Qi, X Pei, X Yu, X Hu… - Pharmacology & …, 2023 - Elsevier
Tumor endothelial cells (TECs) reside in the inner lining of blood vessels and represent a
promising target for targeted cancer therapy. DNA methylation is a chemical process that …
promising target for targeted cancer therapy. DNA methylation is a chemical process that …
CRISPR-mediated modification of DNA methylation pattern in the new era of cancer therapy
F Maroufi, A Maali, M Abdollahpour-Alitappeh… - …, 2020 - Taylor & Francis
In the last 2 decades, a wide variety of studies have been conducted on epigenetics and its
role in various cancers. A major mechanism of epigenetic regulation is DNA methylation …
role in various cancers. A major mechanism of epigenetic regulation is DNA methylation …
[HTML][HTML] Expression and prognosis analysis of TET family in acute myeloid leukemia
T Zhang, Y Zhao, Y Zhao, J Zhou - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
TET family members (TETs) encode proteins that represent crucial factors in the active DNA
demethylation pathway. Evidence has proved that TET2 mutation is associated with …
demethylation pathway. Evidence has proved that TET2 mutation is associated with …