Naloxone dosing in the era of ultra-potent opioid overdoses: a systematic review

J Moe, J Godwin, R Purssell, F O'Sullivan… - Canadian journal of …, 2020 - cambridge.org
ObjectivesEvaluate the relationship between naloxone dose (initial and cumulative) and
opioid toxicity reversal and adverse events in undifferentiated and presumed fentanyl/ultra …

Effect of intranasal vs intramuscular naloxone on opioid overdose: a randomized clinical trial

P Dietze, M Jauncey, A Salmon, M Mohebbi… - JAMA network …, 2019 - jamanetwork.com
Importance Previous unblinded clinical trials suggested that the intranasal route of naloxone
hydrochloride was inferior to the widely used intramuscular route for the reversal of opioid …

Past, present, and future of lipid resuscitation therapy

MR Fettiplace, G Weinberg - Journal of Parenteral and Enteral …, 2015 - Wiley Online Library
Lipid resuscitation therapy was identified in 1998 as an effective treatment for local
anesthetic systemic toxicity in an animal model. Since the original observation, the field has …

Individual and community factors associated with naloxone co-prescribing among long-term opioid patients: a retrospective analysis

BD Stein, R Smart, CM Jones, F Sheng… - Journal of General …, 2021 - Springer
Background Naloxone co-prescribing to individuals at increased opioid overdose risk is a
key component of opioid overdose prevention efforts. Objective Examine naloxone co …

Wearable biosensors have the potential to monitor physiological changes associated with opioid overdose among people who use drugs: A proof-of-concept study in …

AM Roth, NK Tran, B Cocchiaro, AK Mitchell… - Drug and alcohol …, 2021 - Elsevier
Introduction Wearable biosensors have the potential to monitor physiological change
associated with opioid overdose among people who use drugs. Methods We enrolled 16 …

Incoming medical students' knowledge of and attitudes toward people with substance use disorders: Implications for curricular training

TE Moses, M Chammaa, R Ramos… - Substance …, 2021 - journals.sagepub.com
Background Medical students may be in an ideal position to identify patients with substance
use disorders (SUDs) and provide them with information about harm reduction and …

Dispensing naloxone without a prescription: survey evaluation of Ohio pharmacists

EL Thompson, PSS Rao, C Hayes… - Journal of pharmacy …, 2019 - journals.sagepub.com
Background: The Centers for Disease Control and Prevention (CDC) reports a 200%
escalation in the rate of opioid overdose deaths in the United States. Unfortunately, Ohio has …

Monitoring hospitalized adult patients for opioid-induced sedation and respiratory depression

CR Jungquist, K Smith, KLW Nicely… - AJN The American …, 2017 - journals.lww.com
Opioid analgesics are commonly administered to hospitalized patients to treat acute pain,
but these drugs put patients at risk for serious adverse events, such as unintended …

From unwitnessed fatality to witnessed rescue: pharmacologic intervention in sudden unexpected death in epilepsy

GB Richerson, D Boison, CL Faingold, P Ryvlin - Epilepsia, 2016 - Wiley Online Library
The mechanisms of sudden unexpected death in epilepsy (SUDEP) have been difficult to
define, as most cases occur unwitnessed, and physiologic recordings have been obtained in …

A nanoantidote alleviates glioblastoma chemotoxicity without efficacy compromise

M Tian, R Xing, J Guan, B Yang, X Zhao, J Yang… - Nano Letters, 2021 - ACS Publications
Cancer patients suffer from the toxicity of chemotherapy. Antidote, given as a remedy limiting
poison, is an effective way to counteract toxicity. However, few antidotes abrogate …