Anti-cancer effects of cinnamon: Insights into its apoptosis effects

S Sadeghi, A Davoodvandi, MH Pourhanifeh… - European journal of …, 2019 - Elsevier
Cancer is known as a leading cause of death worldwide. In the last two decades, the
incidence of cancer has been dramatically increased mostly due to lifestyle changes. The …

[HTML][HTML] STAT3 signaling in ovarian cancer: a potential therapeutic target

R Liang, X Chen, L Chen, F Wan, K Chen, Y Sun… - Journal of …, 2020 - ncbi.nlm.nih.gov
Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3
(STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently …

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

A Schink, K Naumoska, Z Kitanovski, CJ Kampf… - Food & function, 2018 - pubs.rsc.org
Purpose: Inflammatory processes are involved in many diseases. The bark of Cinnamomum
verum and its extracts are well known for anti-inflammatory effects, but the underlying active …

Anticancer potential and molecular mechanisms of cinnamaldehyde and its congeners present in the cinnamon plant

S Banerjee, S Banerjee - Physiologia, 2023 - mdpi.com
Background: Today, cancer is the leading cause of death. It appears that using large
amounts of natural resources reduces the damaging consequences of cancer therapy. Over …

Activation of STAT3 and STAT5 signaling in epithelial ovarian cancer progression: mechanism and therapeutic opportunity

CJ Wu, V Sundararajan, BC Sheu, RYJ Huang, LH Wei - Cancers, 2019 - mdpi.com
Epithelial ovarian cancer (EOC) is the most lethal of all gynecologic malignancies. Despite
advances in surgical and chemotherapeutic options, most patients with advanced EOC have …

Placental diabesity: placental VEGF and CD31 expression according to pregestational BMI and gestational weight gain in women with gestational diabetes

A Sirico, ED Rossi, VA Degennaro, V Arena… - Archives of Gynecology …, 2023 - Springer
Purpose The aim of this study is to investigate the placental expression of VEGF and CD31
in pregnancies complicated by gestational diabetes (GDM) and the influence of …

The inhibition of hypoxia‐induced angiogenesis and metastasis by cinnamaldehyde is mediated by decreasing HIF‐1α protein synthesis via PI3K/Akt pathway

K Patra, S Jana, A Sarkar, DP Mandal… - Biofactors, 2019 - Wiley Online Library
Tumor hypoxia is positively correlated with tumor aggressiveness and hence is a negative
prognostic factor in cancer. As normal cells usually do not experience such low oxygen …

Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance

R Ezzeddini, M Taghikhani, A Salek Farrokhi… - Journal of physiology …, 2021 - Springer
Lipid metabolism rewiring in gastric adenocarcinoma (GA) pathogenesis is still not clearly
elucidated. This study aimed to describe the role of lipid catabolism in GA patient outcomes …

Cinnamaldehyde induces apoptosis and reverses epithelial-mesenchymal transition through inhibition of Wnt/β-catenin pathway in non-small cell lung cancer

C Wu, Y Zhuang, S Jiang, F Tian, Y Teng… - … International Journal of …, 2017 - Elsevier
Cinnamaldehyde, the main chemical component of the essential oil separated from the
traditional herb Cinnamomum cassia, has been demonstrated to be an efficient cytotoxic …

Dual effects of Chinese herbal medicines on angiogenesis in cancer and ischemic stroke treatments: role of HIF-1 network

M Hong, H Shi, N Wang, HY Tan, Q Wang… - Frontiers in …, 2019 - frontiersin.org
Hypoxia-inducible factor-1 (HIF-1)–induced angiogenesis has been involved in numerous
pathological conditions, and it may be harmful or beneficial depending on the types of …